None listed
Conditions
Brief summary
Common in contact sport, contusion injuries occur when a muscle is subjected to a sudden, forceful impact resulting in damage to the muscle microstructure, inflammation and eventual repair. However, despite the high prevalence of contusion injury in sport, research directly investigated methods to speed up recovery and alleviate injury related pain in humans is lacking. Derived from the plant Cannabis sativa, cannabidiol (CBD) has been shown to have strong anti-inflammatory and modest antioxidant properties that may prove valuable in moderating the effects of soft tissue injuries. Therefore, the primary purpose of this study is to investigate whether CBD oil, ingested sublingually, can alter responses to contusion injury in healthy males. We hypothesise that the use of CBD in the days after injury will alleviate pain and improve recover of muscle function and activation compared to a placebo.
Interventions
Following baseline measures of muscle function, activation and pain, participants will be asked to lie on a padded bed with one leg outstretched. Using a previously established method to induce a contusion injury, a custom-made implement, weighing 7.2kg, will be dropped once down a guide tube from 67cm onto the contracted vastus lateralis (lateral side of the thigh) of one leg. Taking less than half a second, this impact has been shown to produce a force similar to that occurring in contact spor
Following baseline measures of muscle function, activation and pain, participants will be asked to lie on a padded bed with one leg outstretched. Using a previously established method to induce a contusion injury, a custom-made implement, weighing 7.2kg, will be dropped once down a guide tube from 67cm onto the contracted vastus lateralis (lateral side of the thigh) of one leg. Taking less than half a second, this impact has been shown to produce a force similar to that occurring in contact sports and induces a change in muscle function, soreness and swelling for up to 72-hours after impact. Measures of muscle function, activation and pain will be repeated 30 minutes after injury, after which participants will take 1mL of CBD oil or the placebo (medium triglyceride (MCT) oil) sublingually. The treatment will be taken three times daily (morning, midday and evening) over the following three days - up to 72 hours post injury. Each 1mL of CBD oil will provide 120mg of CBD. Participants will be asked to bring the dropper bottle to each visit (24, 48 and 72 hours) so that the volume can be monitored for adherence. Participants will also be asked to report the number of times they took the oil each day. At least two-weeks after the last measures are made for the first trial, the same procedures will be repeated using the other leg and treatment.
Sponsors
Massey University
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy males, aged 18-40 years, who have previously experienced a contusion injury without complication.
Exclusion criteria
• do not have the normal genotype for CBD metabolism • have any current or previous injury to your legs • have had an injury or medical condition that you think may affect your ability to sense pain or discomfort • are taking prescribed medication that may alter your recovery to contusion injury • are taking prescribed medication that may be altered by taking CBD • have an illness that affects your liver • have any disorder of bleeding or clotting of the blood • have any family history of a bleeding disorder such as von Willebrand disease or haemophilia • have had excessive bleeding from trivial wounds that lasted more than 15 minutes or that was recurring spontaneously during the 7 days after the injury • have had a history of prolonged bleeding after a surgical procedure or dental extraction • have had bruising with no apparent or minimal trauma, especially if a lump was felt with the bruise • have had spontaneous nose bleeds that last more than 10 minutes or that required medical attention • have had blood in your stool that was unexplained by diagnosis of a specific condition (eg. Stomach ulcer, polyp in the colon etc) that needed medical attention • have a history of anaemia requiring treatment • have received a blood transfusion • have experienced medical complications as a result of soft tissue/contusion injury in the past • have current bruising to the intended site of contusion
Outcome results
None listed