None listed
Conditions
Brief summary
This study aims to examine the impact of a naturally occurring polyphenol extracted from tea on blood uric acid levels in healthy adults. Researchers will administer the polyphenol to participants and monitor changes in their uric acid concentrations for 6 weeks treatment. The goal is to determine if this tea-derived compound can effectively lower uric acid levels. The study will provide valuable insights into the potential health benefits of tea polyphenols.
Interventions
-Name: polyphenol treatment and placebo
- the dose administered: 100 mg daily
- the duration of administration: 6 weeks and crossover
-the duration of the washout period: 6 weeks
-overall duration of the study: 18 weeks in total, comprising 6 weeks of treatment/placebo, 6 weeks washout and another 6 weeks of treatment/placebo
- the mode of administration: oral tablet
-adherence: Compliance will be monitored by participants recording their consuming time, date of missing dose (if any) by REDCap
-Name: polyphenol treatment and placebo - the dose administered: 100 mg daily - the duration of administration: 6 weeks and crossover -the duration of the washout period: 6 weeks -overall duration of the study: 18 weeks in total, comprising 6 weeks of treatment/placebo, 6 weeks washout and another 6 weeks of treatment/placebo - the mode of administration: oral tablet -adherence: Compliance will be monitored by participants recording their consuming time, date of missing dose (if any) by REDCap survey. Subjects will also be asked to return the unconsumed tablets and empty capsule containers/blister packs at each follow-up visit for capsule counting. Also, the compliance will be monitored by determining quercetin plasma concentrations.
Sponsors
Monash University
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
18 years or more • BMI above 25 kg/m2 • Not a present smoker (cigarette or vape) • Not a regular heavy alcohol drinker (over 1000 mL beers/300 mL wine/90 mL spirits regularly/day) • Not regularly consuming dietary plant-based supplements • Not regularly consuming anti-inflammatory drugs (such as ibuprofen) • Not pregnant, planning on becoming pregnant, breastfeeding • Not diagnosed with heart diseases (cardiovascular, hypertension, etc) or diabetes mellitus, gout and/or kidney disease) • Not have implanted cardiac defibrillator • Not following a medically prescribed diet • Able to adhere to the study protocol and consume capsules provided • Available to attend four testing sessions at the Notting Hill BASE Facility • Have not experienced fainting during blood collection previously
Exclusion criteria
None
Outcome results
None listed