None listed
Conditions
Brief summary
Children commonly display restless and irritable behaviours (known as emergence delirium (ED)) when awakening from general anaesthesia. Usually this is a short-lived and self-limiting problem however it can cause harm if wounds are disrupted, or intravenous lines are dislodged. Additionally, it can be distressing for parents and carers. Ways of reducing the risk of ED have been investigated but none has been shown to reliably prevent it from occurring. Some risk factors are known (for example, younger age, male sex, particular types of anaesthesia and surgery). The microbiome offers a potential insight into various psychological and behavioural conditions, and we wonder whether this might also be the case for ED. If particular microbiome profiles can be associated with different risk profiles and identified in advance of exposure to general anaesthesia, then perioperative management may be altered to reduce the risk of ED.
Interventions
Tonsillectomy under general anaesthesia in children aged 2-7 years
Participants will have stool and oral swab samples collected one week preoperatively to provide specimens for microbiome analysis
Anaesthesia will be standardised and provided by a single anaesthetist for all subjects
Surgery will be standardised and performed or supervised by a single surgeon for all subjects
Participants will be observed in the recovery room to determine whether emergence delirium is present or not; recovery ro
Tonsillectomy under general anaesthesia in children aged 2-7 years Participants will have stool and oral swab samples collected one week preoperatively to provide specimens for microbiome analysis Anaesthesia will be standardised and provided by a single anaesthetist for all subjects Surgery will be standardised and performed or supervised by a single surgeon for all subjects Participants will be observed in the recovery room to determine whether emergence delirium is present or not; recovery room stay is anticipated to be under 4 hours in most subjects After exiting the recovery room, no further observation of subjects will be undertaken; all remaining data will be from the clinical record or already collected samples
Sponsors
Albury Wodonga Health
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Healthy volunteers
No
Inclusion criteria
Children aged 2-7 years undergoing elective tonsillectomy Parent(s) able to read and speak English
Exclusion criteria
Children receiving antibiotics within 12 weeks Major medical comorbidity (ASA 3 or greater) Recent gastrointestinal infection
Outcome results
None listed