None listed
Conditions
Brief summary
The study is an Australian multicentre prospective imaging study performing multiparametric MRIs after acute reperfusion treatment for anterior circulation large vessel occlusion with cerebral perfusion, microstructural, metabolic and functional assessment at multiple follow-up time points. The project has received ethical approval from the Melbourne Health Human Research Ethics Committee (HREC). The HREC confirms that your proposal meets the requirements of the National Statement on Ethical Conduct in Human Research (2007). This HREC is organised and operates in accordance with the National Health and Medical Research Council’s (NHRMC) National Statement on Ethical Conduct in Human Research (2007), and all subsequent updates, and in accordance with the Note for Guidance on Good Clinical Practice (CPMP/ICH/135/95), the Health Privacy Principles described in the Health Records Act 2001 (Vic) and Section 95A of the Privacy Act 1988 (and subsequent Guidelines).
Interventions
Adult patients (>18 years-old) presenting to the recruiting comprehensive stroke centres with acute stroke with anterior circulation large vessel occlusion considered for or receiving reperfusion therapies will be recruited for additional serial MRIs and blood tests with follow-up period up to 12 months (performed at MRI at 2-hours post-treatment, 24-72hours, 3 months & 12 months and blood tests at baseline, 2-hour and 24-72hours post-treatment ) as determined by participant's consent to continu
Adult patients (>18 years-old) presenting to the recruiting comprehensive stroke centres with acute stroke with anterior circulation large vessel occlusion considered for or receiving reperfusion therapies will be recruited for additional serial MRIs and blood tests with follow-up period up to 12 months (performed at MRI at 2-hours post-treatment, 24-72hours, 3 months & 12 months and blood tests at baseline, 2-hour and 24-72hours post-treatment ) as determined by participant's consent to continue attending MRIs.
Sponsors
Melbourne Health
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients (>18 years-old) presenting for or receiving reperfusion therapies (e.g. thrombectomy) for acute ischaemic stroke with anterior circulation large vessel occlusion.
Exclusion criteria
Exclusions include inability to give informed consent, contraindications to MRI study (eg. metallic foreign bodies in situ, claustrophobia, pregnancy), medical instability, terminal illness with expected survival less than 1 year. Specific MRI sequences involving Gadolinum will be omitted for patients with significant renal impairment (eGFR <30 ml/min) as per standard practice for the studies.
Outcome results
None listed