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A randomised control trial of digital memory flexibility training (MemFlex) as a stepped care intervention for individuals with post-traumatic stress disorder (PTSD)

A randomised control trial of the effect of digital memory flexibility training (MemFlex) as a stepped care intervention on post-traumatic symptom severity and autobiographical memory in individuals with PTSD

Status
Terminated
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12624000566538
Enrollment
10
Registered
2024-05-06
Start date
2024-05-15
Completion date
2024-07-12
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We have highly effective psychological therapies for post-traumatic stress disorder (PTSD), however, individuals face multiple barriers to receiving gold-standard treatments. Most prolific of these is long waiting times, due to the limited number of professionals trained in specialist PTSD treatments. Here, we aim to evaluate a simple, digital, memory-based program MemFlex, which has been demonstrated to improve PTSD symptoms, and ameliorate cognitive difficulties that predict prognosis and impede the efficacy of psychological therapy. It is expected that offering MemFlex to individuals on the waitlist for psychological therapies will improve both a) cognitive predictors of PTSD, and b) post-treatment symptoms, relative to waitlist as usual.

Interventions

MemFlex: The MemFlex intervention aims to improve the ability to retrieve any autobiographical memory type on demand, using cued recall exercises. Participants are never asked to retrieve negative memories or trauma memories. In particular, the intervention trains three core skills: balancing, elaboration, and flexibility. Balancing aims to improve access to personally relevant memories that are emotionally positive. Improving ease of access to positive autobiographical information aims to balance against the negative self-appraisals that drive PTSD. Elaboration aims to increase the detail and vividness of these positive memories. Flexibility explicitly trains the ability to move between specific and general levels of memory representation. These skills are gradually introduced and build upon via eight online self-guided sessions. A 45 minute Zoom call with a support worker introduces the intervention. Participants are emailed a link to access the online sessions, which involve an initial psychoeducation component, and memory recall exercises using memory cues. In the sessions, participants are trained to recall event memories and general memories, to elaborate memories with contextual, emotional and somatic details, and to flexibly move between memory types. Participants are encouraged to complete two online, self-guided sessions (~20 mins) per week for 4 weeks, and can contact the worker with any questions. Treatment adherence is monitored by the support worker through website analytics. The worker will also check in with participants 2 weeks into the trial. MemFlex participants will be able to continue any other offered activities (e.g., medication). That is, a MemFlex+ treatment as usual (in this case, waitlist for psychiatry services at Phoenix Australia) design will be used. Amendment: Following participant feedback from the first five participants allocated to the MemFlex condition, the text of the online sessions has been reduced to enhance understanding and minimise participant burden. The core information contained in the intervention, and the intervention exercises, remain the same.

Sponsors

The University of Melbourne
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator)

Eligibility

Sex/Gender
All
Age
17 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Deemed eligible for trauma-focussed treatment services at Phoenix Australia, proficient in reading and writing in English, and have access to a computer.

Exclusion criteria

Severe cognitive impairment.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026