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Efficacy of Viable Cartilage Allograft in talar osteochondral lesions

Efficacy of Viable Cartilage Allograft in talar osteochondral lesions

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12624000412538
Acronym
eVAC
Enrollment
10
Registered
2024-04-04
Start date
2024-05-01
Completion date
Unknown
Last updated
2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Osteochondral lesion in talus can be challenging to treat leading to ongoing pain and loss of function. This study aims to investigate the efficacy of viable cartilage allograft for osteochondral talar dome lesions. The study hypothesis is: In patients with talus osteochondral lesions, viable cartilage allograft can improve patient pain and function.

Interventions

Osteochondral lesion of the talus are common and can be present in upto 6.5% of the population. While some may be asymptomatic, others can cause pain affecting lifestyle and potential lead to accelerated wear and potential arthritis. Traditionally microfracture has been the mainstay of surgical treatment however this can be associated with ongoing symptoms. The purpose of this pilot study is to assess the clinical efficacy of viable cartilage allograft in treating talar osteochondral lesions. P

Osteochondral lesion of the talus are common and can be present in upto 6.5% of the population. While some may be asymptomatic, others can cause pain affecting lifestyle and potential lead to accelerated wear and potential arthritis. Traditionally microfracture has been the mainstay of surgical treatment however this can be associated with ongoing symptoms. The purpose of this pilot study is to assess the clinical efficacy of viable cartilage allograft in treating talar osteochondral lesions. Patients enrolled in the study will receive Viable cartilage allograft. The viable cartilage allograft (CartiMax) is supplied by CONMED corporation. As part of the procedure, an ankle arthroscopy will be performed in an operating theatre of a an Australian hospital. The lesion will be identified, prepared and the viable cartilage allograft will then be inserted. The surgery will take approximately 60 minutes. The surgeons involved are Australian trained foot and ankle orthopaedic surgeons with a number of years of experience. The surgeon performing the surgery will be implanting the allograft.

Sponsors

Sydney Orthopaedic Foot and Ankle Research Institute
Lead SponsorOther

Study design

Allocation
Non-randomised trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

Patients between the ages of 18 to 65 (inclusive) undergoing surgery to treat talar osteochondral lesions will be included.

Exclusion criteria

Exclusion criteria will be bilateral surgery, revision procedures, not willing to participate in the trial, cognitive impairment that may impair the patient’s ability to follow post-operative instructions or unable to provide informed consent.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026