None listed
Conditions
Brief summary
This study is looking at follicular unit extraction to treat hidradenitis suppurativa, a condition that causes inflammation of hair follicles resulting in severe pain and scarring. Follicular unit extraction is a technique used in hair transplants to entirely remove hair follicles. We want to test whether or not by removing hair follicles using hair follicle extraction technique reduces inflammation and improve the quality of patients’ life. We will do hair follicle extraction on both sides of either the armpit or groin and compare it with topical routine treatments to assess whether or not there is improvement. We will follow the participants until week 24 of the study.
Interventions
This is a prospective, interventional study to evaluate the effectiveness of follicular unit extraction (FUE) in reducing severity score of mild to moderate Hidradenitis suppurativa (HS).
Follicular unit excision (FUE) is a minimally invasive surgical technique used in hair transplantation surgery where hair grafts are extracted from the donor area and implanted in the recipient area under local anaesthesia. In FUE, the skin around a follicular unit is scored using a 0.8-1 mm circular punch mou
This is a prospective, interventional study to evaluate the effectiveness of follicular unit extraction (FUE) in reducing severity score of mild to moderate Hidradenitis suppurativa (HS). Follicular unit excision (FUE) is a minimally invasive surgical technique used in hair transplantation surgery where hair grafts are extracted from the donor area and implanted in the recipient area under local anaesthesia. In FUE, the skin around a follicular unit is scored using a 0.8-1 mm circular punch mounted on a motorized hand device, and the graft is subsequently extracted. The extraction leaves a wound which heals by secondary intention. Residual scars are pin-point dots which are virtually imperceptible to the naked eye. Participants will be taken to the procedure room. Local anaesthesia will be injected into diseased hair-bearing area on both sides of either the axillae or groin. FUE will be performed by the investigator (who is experienced in FUE) using 0.8/0.9/1.0 mm Ertip® punch. The extracted hair follicular unit samples will have histopathological analysis to confirm complete removal of hair follicles, sebaceous glands, aporcrine glands and eccrine glands. These samples are not kept for future studies and will be discarded once complete removal of the pilosebaceous units are confirmed. Participants will not be charged for samples being analysed to confirm complete removal of the pilosebaceous units. The follicular unit extraction will take approximately 2 hours to complete. Participants will have 3 subsequent follow ups after the FUE to assess wound healing as well as HS severity. *Please note that there will be no implantation involved in this procedure. Follicular unit extraction is a technique used in hair transplantation surgeries however this technique will be adopted in this intervention to assess the validity of this technique for HS patients.
Sponsors
Dr Bevin Bhoyrul
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male and female patients with HS aged 18 years and above 2. Mild-moderate HS defined by Hurley stage 1 up to 2A 3. Minimum diagnosis of 3 months prior to baseline 4. Active HS present for at least 3 months from initial diagnosis.
Exclusion criteria
1. Current treatment with antibiotics, retinoids, immunosuppressants or biologic agents at the discretion of the investigator/research team. 2. Extensive scarring. 3. Absence of terminal hairs in target areas. 4. Previous laser hair removal in target areas. 5. Pregnant or lactating women
Outcome results
None listed