None listed
Conditions
Brief summary
Sleep is an important activity for ensuing health and recovery from illness. Sleep deprivation is known to be associated with several comorbidities including obesity, diabetes, anxiety and depression, hypertension, heart disease and stroke and increased risk of death. Sleep deprivation is also known to be associated with impaired cognition, impaired immune function and could make people less morally aware. Sleep in intensive care unit (ICU) was shown to be of a poor quality by several studies including from our group. However many of these studies assessed sleep using subjective tools such as Richard Campbell Sleep Questionnaire, self-reported sleep quality by patients and nurse, or clinician observations. These subjective tools, while they are simpler to use, are not reliable and can over- or underestimate the sleep quality and duration. Some objective tools such as Actigrapy and Bispectral Index were used for sleep evaluation but are not gold standard to evaluate sleep. In this study we propose to use Polysomnography which is considered to be gold standard for studying sleep. We aim to study the sleep of patients who are on a mechanical ventilator and receiving some of the commonly used drugs to promote sleep.
Interventions
The aim is to investigate the drug induced sleep quality in critically ill patients using polysomnography. Patients will be receiving drug(s) to assist with their management including sedation regardless of their involvement in this study. The drugs that are used for sedation in intensive care include Dexmedetomidine, melatonin, Lemborexant, gabapentin, Fentanyl, propofol or midazolam. These drugs are given to the duration of patients while they require mechanical ventilation. For the purpose of
The aim is to investigate the drug induced sleep quality in critically ill patients using polysomnography. Patients will be receiving drug(s) to assist with their management including sedation regardless of their involvement in this study. The drugs that are used for sedation in intensive care include Dexmedetomidine, melatonin, Lemborexant, gabapentin, Fentanyl, propofol or midazolam. These drugs are given to the duration of patients while they require mechanical ventilation. For the purpose of this study, we specifically will assess Dexmedetomidine, melatonin, Lemborexant, gabapentin for 3 days only with polysomnography that studies brain electrical activity to help in understanding the sleep quality.
Sponsors
Peninsula Health, Frankston Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients are on invasive mechanical ventilation and are expected to stay on the mechanical ventilator for at least 72 hours from the time of study inclusion.
Exclusion criteria
Patients currently requiring paralytic agents, suspected to have ongoing seizures, admitted with a diagnosis of stroke, Guillain Barre Syndrome, traumatic brain injury current or past, cardiac arrest,
Outcome results
None listed