None listed
Conditions
Brief summary
Steroid therapy and outcome of parapneumonic effusion in children is a randomized controlled trial.This study is planned to explore efficacy of dexamethasone as an adjunct therapy with standard antibiotics in children with parapneumonic effusion.Primary hypothesis is that dexamethasone will improve clinical outcome by reducing pleural and systemic inflammation in patients with pneumonia related pleural effusion and have acceptable safety profile.
Interventions
interventional drug dexamethasone, 0.25mg/kg , Intravenous infusion , 6 hourly , for 2 days will be given along with standard treatment(antibiotic therapy)
.it will be prescribed by pediatrician, delivered and monitored by ward nurses.
participants will be allowed to take other drugs/treatments related to the care of their parapneumonic effusion/pneumonia or other comorbidities and it will be recorded.
Sponsors
University of child health sciences,Children hospital Lahore
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
2 Months to 14 Years
Healthy volunteers
No
Inclusion criteria
Children (2 mo-14 y) admitted for pneumonia (defined as fever >1oo.4 F with cough and chest radiography showing parenchymal lesion) with pleural effusion.
Exclusion criteria
Immunodeficiency/chronic lung conditions, Hemodynamic instability requiring cardiac / ventilator support ,Allergy to any of the drugs included in study, Contraindications to steroids, children already taking steroid therapy, Known diabetics, Children with comorbid conditions, ,Active tuberculosis, Blood glucose level above 200 mg/dl at time of enrolment
Outcome results
None listed