Influence of Clindamicyn and Amoxicillin in early dental implant failure

Influence of preoperative clindamicyn and amoxicillin in reducing early dental implant failure. A randomised controlled clinical trial.

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12624000324516

Enrollment

Registered

2024-03-25

Start date

2024-06-18

Completion date

2024-06-25

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to compare the use of preoperative Clindamycin 600mg in non allergic penicillin patients in comparison with 2g Amoxicillin 1h before dental implant surgery in relation with early dental implant failure. In penicillin allergic patients there is an increase of early dental implant failure when clindamycin is used in comparison with non allergic when amoxicillin is used. There is only one clinical trial comparing Clindamycin versus placebo. All the previous studies use a postoperative antibiotic regimen with clindamycin that may affect increasing early dental implant failure.

Interventions

Prophylactic use of Clindamycin 600mg or Amoxicillin 2g 1hour prior dental implant surgery. In both cases the mode of administration by oral tablets. In order to monitor the patient adherence, they will return the drug tablet after the administration.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Susceptible healthy patients for dental implants in molars and premolars at least 18 years old. Periodontal controlled patients

Exclusion criteria

Inmunocompromised patients Diabetes patients Areas in which a bone or soft tissue regeneration is needed Post extraction dental implants Inmediate loading dental implants allergy to any drugs used in the trial Decompensated systemic pathologies (cardiac, respiratory, endocrine, metabolic, hepatic, haematological, the risk of bacterial endocarditis, or immunosuppression)oking patients Smokers history or use of bisphosphonates, anticoagulants, or antiplatelet agents Patients with amannesis reports that they have had been irradiated in the cervical and maxillofacial territory, were pregnant, suspected of being pregnant or breastfeeding, or with a history of antibiotic-associated ulcerous colitis.

Outcome results