None listed
Conditions
Brief summary
Malnutrition, sarcopenia, and cachexia are common concerns for patients with pancreatic cancer, causing increased risk of comorbidities and may affect their ability to respond to cancer treatments. This study aims to assess the feasibility and effectiveness of an out-patient dietetics program on nutritional status and quality of life in individuals with pancreatic cancer. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with pancreatic cancer and you are due to begin your cancer therapy within the next month. Study details You will be assessed by a dietitian within the first month of your treatment. Basic health and nutrition information will be collected including your age, weight, cancer stage and treatment, symptoms impacting your nutrition (such as nausea, vomiting, or treatment side effects), and diet history. Individual nutrition recommendations will be provided to optimise your nutritional intake, which might involve consuming oral nutrition supplements. If you have not started therapy, education will be provided regarding your upcoming treatment and how this might impact your nutrition afterwards. The number of times you will be seen by a dietitian will depend on your nutrition status and how much support you require. You will be requested to complete questionnaires to help us understand your nutritional status, quality of life, and satisfaction with the dietetics program. It is hoped this research will determine that dietary counselling for patients with pancreatic cancer is feasible and acceptable to these patients. This pilot study will assess whether there is potential benefit in delivering this service to a greater number of patients with pancreatic cancer in a larger randomised trial.
Interventions
Enrolled participants will have the choice to attend an in-person dietetics consultation at their nearest Epworth HealthCare facility. However, if attending in-person is not convenient or feasible, telehealth consultations will be available. These virtual sessions can be conducted either over the phone or through Microsoft Teams. The frequency of follow-up consultations will be tailored based on the patient’s prognosis, treatment plan, and the health status as per ESPEN practical guidelines. Dietetic assessment and review: • BMI, PG-SGA (malnutrition) questionnaire, SARC-F (sarcopenia) questionnaire • Clinical symptoms and situation: Including nausea, vomiting, bowel function, treatment plan and side effects (if applicable), operative plan (if applicable) • Dietary intake: - Review current dietary intake, changes/impacts from clinical situation, implementation of previous dietetic strategies (if applicable) using a food diary template designed specifically for this study. - Assess whether meeting estimated energy and protein requirements in line with ESPEN guidelines for preventing/treating malnutrition pre-operatively. Dietetic intervention: • Strategies to maintain weight prior to systemic therapy and to enhance oral intake if currently suboptimal i.e., high calorie high protein meal fortification, oral nutrition supplements such as Fortisip®/Resource® will be measured via weight chart designed specifically for this study. • Consideration of escalated nutrition support via artificial feeding if oral intake severely suboptimal or patient severely malnourished (liaise with treating team). • Participants will be provided written handouts of the nutrition counselling session, as needed. • They will also receive nutrition pamphlets to further highlight common side-effects of treatment, such as loss of appetite and weight loss. These are readily available resources located on the Jreissati Pancreatic Centre website: https://www.epworth.org.au/-/media/project/epworth/epworthweb/documents/services/jreissati-family-pancreatic-centre/pi2429-jpc-nutrition-guide-a5-v6-web.pdf Frequency of follow-up Follow-up appointments will be scheduled according to nutrition risk stratification at diagnosis/planning and pre/post therapy. For instance, participants with a PG-SGA assessment of ‘B’ or ‘C’ (i.e., malnourished) may require additional dietetic review to optimise their nutrition, compared to a participant with a PG-SGA 'A' assessment whose dietary intake is likely adequate. Individuals who are considered low risk (A assessment) will be followed-up every month. Those in moderate risk (B assessment) will be followed up via telehealth or clinic review every 1-2 weeks. Individuals at severe risk (C assessment) will require 1-2 telehealth/clinic reviews per week or inpatient admission. The frequency of these follow-ups will occur over a maximum duration of a year.
Sponsors
Study design
Eligibility
Inclusion criteria
Participants must meet all the following criteria: - Aged at least 18 years at the time of consent - Planned for systemic therapy - Provide written informed consent prior to any study procedures and agree to adhere to all protocol requirements - Confirmed histological or cytological diagnosis of pancreatic cancer. - No later than one-month post commencement of systemic treatment, including chemotherapy, biological therapy, radiotherapy, or targeted therapy for pancreatic cancer. - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 2. - Has a life expectancy of greater or equal to 6 months.
Exclusion criteria
Participants must not meet any of the following criteria: - Currently enrolled in a weight management program, receiving nutritional counselling, or part of another nutrition-related study/program.