Effectiveness of high protein supplementation on muscle mass and function among older adults with sarcopenia

Efficacy of high protein supplementation on body composition and muscle function among older adults with sarcopenia: a randomized controlled trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12624000277549

Enrollment

Registered

2024-03-18

Start date

2021-12-30

Completion date

2023-07-12

Last updated

2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to investigate the impact of high protein supplement (HPS) on older adults with low muscle mass and muscle function. We hypothesize that HPS consumption for 12 weeks can improve one's muscle mass (assessed using body composition analyzer and MRI) as well as muscle function (assessed through a series of physical tests), when compared to another group of participants who consume placebo supplements. Both researchers and participants will only know which supplements the latter are on after they complete the whole trial.

Interventions

- Participants will be given oral and written instruction by principal researcher on how to consume the high protein supplementation - Type of intervention: high protein supplements - Serving instruction: to dissolve the said supplement in 160ml of lukewarm/cold water, stir well and consume - Supplement content (per sachet): 174kcal, 25.1g protein (whey protein concentrate), 3.0g leucine, 10.2g carbohydrates, 3.1g fat, 2.5g fiber, 10ug vit. D3, 12mcg vit. K - The number of times the intervention will be delivered: 2 sachets daily for 12 weeks - Location of intervention: participant's home - Compliance monitoring: WhatsApp text and/or call will be made to each participant once a week to ensure their compliance

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

Aged 60 and above Skeletal muscle index (SMI) <7.0kg/m2 (male) or <5.7kg/m2 (female)

Exclusion criteria

Poorly controlled diabetes, chronic kidney disease stage 3a and below, gastrointestinal diseases, milk/soy intolerance or allergy

Outcome results