None listed
Conditions
Brief summary
Climatologists currently estimate that the environmental threshold for human heat tolerance is 6 hours at a wet-bulb temperature (Twet) of 35 °C. When accounting for human physiological thermoregulatory variables such as metabolic heat production and sweating capacity, however, it is likely that this threshold is severely underestimated. Contrary to the assumptions made by the 35 °C Twet model, in real-world scenarios, people expend anywhere between 1.5 to 5.0 METs to perform activities of daily living, and the ability to cool down through sweating is limited in certain conditions. Specifically, in very humid environments, evaporative capacity is limited by a low vapour pressure gradient between the air and skin; whereas in very dry environments, it is limited by the ability of the body to produce sweat. This is an important distinction because the same Twet can be represented by different combinations of air temperature and relative humidity, which means that the limiting factor to achieving heat balance will be different depending on the environmental conditions being experienced. It is more than likely that the limits to human heat tolerance are not represented by a universal Twet temperature threshold, but rather differ based on the type of heat stress an individual is exposed to (i.e., humid vs. dry). This theory has only ever been modelled and has never been tested in human subjects which is imperative to moving this area of research forward.
Interventions
Participants will undergo 7 consecutive days of exercise heat acclimation in pairs in the Thermal Ergonomics Laboratory's climate chamber (University of Sydney) set to 40 °C, 50% relative humidity (RH). The protocol will involve 90 minutes of treadmill running at an individualized target of ~70-75% of maximal heart rate. These sessions will be supervised by qualified research personnel (i.e., undergraduate or post PhD-level exercise science/physiology trainees), and adherence will be assessed as the number of sessions completed out of 7. In the same pairs, participants will then undergo 3-hour (maximum) exposures to all 4 different extreme heat conditions in the climate chamber (University of Sydney), with exposures separated by at least 48 hours: 1. Hot, very humid (HVH): 38 °C, 81.1% RH (Twet equal to 35.00 °C) 2. Hot, humid (HH): 46 °C, 45.8% RH (Twet equal to 35.00 °C) 3. Very hot, dry (VHD): 54 °C, 26.2% RH (Twet equal to 34.99 °C) 4. Very hot, very dry (VHVD): 54 °C, 13.1% RH (Twet equal to 28.54 °C) For all exposures, participants will remain seated in the chamber and will be allowed to drink water ad libitum. Intervention fidelity will be assessed through laboratory observation and monitoring by the researcher.
Sponsors
Study design
Eligibility
Inclusion criteria
18-40 years old Generally healthy Able to read and understand English in order to provide informed consent to participate in the study
Exclusion criteria
Those with contraindications to rectal temperature measurement (e.g., haemorrhoids, heterotopic ossification, rectal bleeding or bleeding disorder, fissures or active infections, anticoagulant therapy, colitis) Smokers Pregnancy Currently diagnosed or those that possess a history of hypertension, cardiovascular, respiratory and/or metabolic disorders Medication use related to any of the above conditions