None listed
Conditions
Brief summary
Ondansetron was proved to decrease pain on propofol injection. Lidocaine also has a role on pain on propofol injection. This study is aimed to determine efficacy of ondansetron as an adjunct to lidocaine in pain on propofol injection compared with lidocaine alone.
Interventions
20mg lidocaine (2% preservative-free) with 4mg ondansetron was prepared and was administered intravenously at the 3-way stop cock in 5 seconds by the nurse then the 3-way stop cock was locked for 15 seconds before 50 mg of propofol was administered in 5 seconds by the anesthesiologist.
Sponsors
King Chulalongkorn Memorial Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
-ASA classification I-II -scheduled for elective surgery with general anesthesia -Age 18- 60 years old -Weight more than 50 kg. -cooperate and able to communicate
Exclusion criteria
-patient's refusal -did not use propofol as induction agent -IV catheter 20G can't be accessed -local infection at IV site -Allergic to ondansetron or lidocaine -History of cardiac arrhythmia -unable to assess the pain score -chronic pain or receive analgesic 24 hours before surgery -RSI technique was used
Outcome results
None listed