None listed
Conditions
Brief summary
Poor diet is common and is associated with suboptimal outcomes for people with MS leading to higher health care expenditure. The impact of dietary patterns on disease incidence and progression in MS remains controversial with limited interventional studies. Moreover, the impact of improved diet quality on brain biochemical composition of MS has not been explored. This study intends to investigate the effects of improving diet quality in MS . Online telehealth dietary intervention by professional dietitians will measure diet quality and intake to ensure optimal dietary intake. A novel MRI method will be used to measure neurometabolites changes pre- and post-intervention which is able to assess the value of dietary improvement in an effective time frame.
Interventions
The dietary intervention involves the following: All participants will receive personalised dietary advice from a dietitian for the 3-month intervention, where the dietitian will provide instructions and nutritional advice, with the end goal of improving diet quality.
Five telehealth sessions over three months facilitated by a dietitian experienced in motivational interviewing (MI).
These consultations (5 telehealth appointments for improving diet quality) will occur at baseline, 2 weeks, 4 week
The dietary intervention involves the following: All participants will receive personalised dietary advice from a dietitian for the 3-month intervention, where the dietitian will provide instructions and nutritional advice, with the end goal of improving diet quality. Five telehealth sessions over three months facilitated by a dietitian experienced in motivational interviewing (MI). These consultations (5 telehealth appointments for improving diet quality) will occur at baseline, 2 weeks, 4 weeks, 8 weeks, and 3 months. The duration of the telehealth intervention consultations will be as follows: Baseline: 45 minutes Weeks 2, 4, and 8: 30 minutes each 3-month session: 45 minutes. The dietary intervention will be administered by a qualified and experienced dietitian. These periodic telehealth sessions will monitor and motivate the participants to adhere to the diet intervention. Also to ensure optimal dietary intake which will be facilitated via the provision of weekly boxes of fruits and vegetables for 3 months. The dietary intervention is not individualised, All MRIs will be conducted on a 3T Siemens Clinical Research Scanner (Prisma) at the Hunter Medical Research Institute (HMRI) using a 64-channel head and neck coil. • Participants will undergo two MRI scans: one at baseline (prior to the intervention) and another at three months (post-intervention). • Each MRI scan session will require 60 minutes in total and will take place at the HMRI Imaging Centre. MRI Measurements: Three-dimensional MRI for the evaluation of total brain volumes, lesion volumes, and thalamic volumes. MRSpectroscopy for the quantification of brain metabolites in multiple brain regions. .
Sponsors
University of Newcastle
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
• people with Multiple Sclerosis • Age 20-65 years • EDSS 0.0-6.0 • Disease duration <15 years • Clinically stable (no relapse or DMT change within last 6 months) • On regular and unspecialised diet for at least 6 months.
Exclusion criteria
• Any contraindication to MRI scanning including: o Cardiac pacemaker o Cardiac defibrillator o Metal fragments in the eye o Any other non-MRI compatible medical device/implant or medical condition o Severe claustrophobia • Special dietary requirements, nutritional deficiencies or people with haemochromatosis or dysphagia • Diabetes • Food allergies or coeliac disease • Vegetarians or vegans • Severe depression or suicidal thoughts • Individuals with diagnosed and/or history of eating disorders. • Pregnant/planning to fall pregnant for the duration of the study.
Outcome results
None listed