Skip to content

Understanding Knee Health and Knee Sounds in People with Knee Crepitus

The exercise physiology knee clinic study - linking knee sounds and knee health

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12624000156583
Enrollment
50
Registered
2024-02-19
Start date
2024-03-04
Completion date
2024-10-07
Last updated
2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to understand whether different types of knee sounds are associated with knee issues. We also would like to understand perceptions that people have regarding their creaky knees and usefulness of an Exercise Physiology assessment session for their knee function and health. The study will ask people, with/without knee osteoarthritis, to attend a 1-hour knee assessment session at the University of Sydney. In this session knee health will be assessed, knee sounds recorded, and exercise advice provided. Three months later the participants will be interviewed about their knee health and if they found the AEP session useful.

Interventions

All study participants will receive client-specific education of exercise and osteoarthritis (OA) by an Accredited Exercise physiologist (AEP)/AEP student (personalised knee health information) in a short verbal exchange (10min) following baseline data collection (conducted by an AEP/AEP student). Advice will focus on engaging in 1) aerobic and resistance exercise, 2) flexibility training and 3) education about OA/crepitus, its prognosis, causes and 4) role of exercise as is standard practice fo

All study participants will receive client-specific education of exercise and osteoarthritis (OA) by an Accredited Exercise physiologist (AEP)/AEP student (personalised knee health information) in a short verbal exchange (10min) following baseline data collection (conducted by an AEP/AEP student). Advice will focus on engaging in 1) aerobic and resistance exercise, 2) flexibility training and 3) education about OA/crepitus, its prognosis, causes and 4) role of exercise as is standard practice for AEPs (Hinman et al., 2023). This will not be recorded. the following outcomes will be assessed during the 1hr study visit to the University of Sydney campus Camperdown: Knee sounds: recorded by handheld sound recording device during lower limb physical health and function outcomes (e.g. squatting). Anthropometry and demographics: height, weight, BMI, waist circumference, age, gender, race, comorbid conditions, history of knee injury/surgery, occupation, resting blood pressure. Questionnaires: Exercise and Sports Science pre-screening tool, Knee Injury and Osteoarthritis Outcome Score, International Physical activity questionnaire (IPAQ), Tampa Scale of Kinesiophobia, Pain self-efficacy questionnaire, Pain catastrophising scale, Patient global impression of change scale. Qualitative: participant perceptions/interpretation of crepitus, function, pain and related exercise behaviours (short semi-structured interview). Physical health and functional capacity: 3-repetition maximal (3-RM) strength test of knee extension, knee flexion, and leg press, timed up and go (TUG) test. Immune cells and biomarkers: blood sampling of venous blood (10mL total) -optional (and may occur on a different day/time). 3 months after initial study visit: participant perceptions/interpretation of change in crepitus, function, pain and related exercise behaviours and perceptions of the initial AEP clinic visit (short semi-structured interview).

Sponsors

University of Sydney
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

• Greater than 18 years of age. • Any of knee crepitus, knee osteoarthritis or concerns regarding knee health. • Willingness to provide informed consent and comply with the study requirements.

Exclusion criteria

• Total knee replacement. • Recent surgery (<6 months). • Uncontrolled psychiatric illness. • Recent onset cardiovascular disease (coronary artery disease, myocardial infarction, etc, <6 months). • Musculoskeletal pathology that would impede capacity to carry out the exercise assessments and intervention. • Participants who are not fluent in English or who have difficulty understanding English. • Other form of arthritis. • Pregnancy.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026