Brain connectivity in children under 4 months of age undergoing general anesthesia

Characterization of the states of consciousness during general anesthesia in children under 4 months of age through electroencephalographic analysis of brain connectivity

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12624000069550

Enrollment

Registered

2024-01-29

Start date

2024-01-31

Completion date

2024-10-31

Last updated

2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We hypothesize that it is possible to characterize the different states of consciousness during general anesthesia with sevoflurane in children less than 4 months after surgery through electroencephalographic analysis of functional brain connectivity. A convenience sample will be taken between September 2023 and October 24 of children under 4 months of age undergoing surgical procedures under general anesthesia with Sevoflurane at the Red Cross Children's Hospital in Manizales who meet the inclusion criteria. A Cadwell Easy III brand 16-channel EEG will be used, which will be located according to the 10/20 system. EEG records will be taken at 4 times: before induction, during anesthetic induction, during surgery, and upon awakening. The data will be processed minimally, following the convention for pediatric data with EEGLAB from MATLAB and analyzed to characterize functional brain connectivity at each of the 4 moments

Interventions

Participants will receive auditory and visual stimuli of 10 seconds during four moments delivered by a rheatre nurse: before anesthetic induction, during anesthetic induction, during surgical incision, and upon awakening. During the four moments, the electroencegalographic signals will be recorded with 16-channel surface EEG located in a 10/20 system. Auditory stimuli of 20 db and light stimuli of 50 cd/m2 will be performed for each ear and for each eye, respectively.

Eligibility

Sex/Gender

All

Age

0 to 4 Months

Healthy volunteers

Inclusion criteria

Babies less than 4 months old, ASA I-II, undergoing general anesthesia

Exclusion criteria

Patients with genetic syndromes, with perinatal hypoxia, neurological disorders, or hemodynamic or metabolic instability

Outcome results