None listed
Conditions
Brief summary
SENTINEL International is a multicountry multicentre retrospective cohort study of children with suspected community-acquired sepsis. This study will use established study processes and materials developed for the SENTINEL study currently being conducted at 12 centres of the Australian and New Zealand through the Paediatric Research in Emergency Departments International Collaborative (PREDICT) research network. The ultimate goal is to prepare for larger scale international interventional sepsis studies in children.
Interventions
This study will collect retrospective data over one calendar year from medical records of children with suspected community acquired sepsis. The precise dates over which data will be collected will vary by site, depending on individual site start time (earliest start date will be June 2024). Details regarding hospitalisation for sepsis will be abstracted, such as treatments provided, adverse events, length of stay, and mortality. No patient assessment will occur for study purposes (including phy
This study will collect retrospective data over one calendar year from medical records of children with suspected community acquired sepsis. The precise dates over which data will be collected will vary by site, depending on individual site start time (earliest start date will be June 2024). Details regarding hospitalisation for sepsis will be abstracted, such as treatments provided, adverse events, length of stay, and mortality. No patient assessment will occur for study purposes (including physical assessments, tests, or surveys). Only hospital details will be recorded, the duration of the study for individual participants is the duration of hospitalisation.
Sponsors
Murdoch Children's Research Institute
Eligibility
Sex/Gender
All
Age
0 to 18 Years
Healthy volunteers
No
Inclusion criteria
Age less than 18 years AND Admission to hospital AND Treatment with intravenous (IV)/ intramuscular (IM)/ intraosseous (IO) antibiotics pre-hospital or in ED AND Circulatory support (fluid bolus or inotropic support) pre-hospital or in ED OR Admission diagnosis of suspected sepsis, septicaemia or septic shock Fluid bolus defined as equal to or greater than 5ml/kg or 500mls administered over less than 30 minutes to treat impaired perfusion (not dehydration) Inotropic support defined as intravenous infusion of inotrope/vasopressor
Exclusion criteria
Patients not initially seen in the Emergency Department (i.e. transferred directly to the ward including ICU) Patients presenting with trauma Patients transferred from another hospital if > 24 hours since presentation
Outcome results
None listed