A Phase 1b, Single-centre, Open-label Study to Evaluate Food Effect and the Drug-Drug Interaction of Omeprazole, Itraconazole and Rifampin on Tinlarebant in Healthy Adult Subjects

This study will be conducted in four independent Parts as follow: Part 1(Tinlarebant+Omeprazole): 12 participants will take tinlarebant (5 mg) on Day 1 and Day 22, and take Omeprazole(40 mg) once daily on each Day 18-26. Part 2 (Tinlarebant+Itraconazole): 12 participants will take tinlarebant (5 mg) on Day 1 and Day 22, and take Itraconazole (200 mg) twice daily on each Day 17-26. Part 3 (Tinlarebant+Rifampin): 12 participants will take tinlarebant (5 mg) on Day 1 and Day 22, and take Rifampin (600 mg) once daily on each Day 14-26. Part 4 (Food Effect): 12 participants will be randomized into two treatment sequences: Sequence 1: to take tinlarebant (5mg) on Day 1 under fasted condition, and Day 22 under fed condition. Sequence 2: to take tinlarebant (5mg) on Day 1 under fed condition, and Day 22 under fasted condition. - Fasted condition: minimum 10 hour fast, water allowed until 1 hour before study drug administration. - Fed condition: participants will have a standard high fat, high calorie meal includes: 2 eggs fried in butter, 2 rashers of bacon, 2 slices of toast with 16 g butter per slice, 125 g of hash browns and 240 mL of full cream milk. All the study drug all be administrated orally, and recorded in dosing diaries at home or Electronic Medical Record on site.