None listed
Conditions
Brief summary
Studies have shown that capsaicin may possibly be effective against weight gain and fat accumulation by inhibiting fat absorption and activating fat metabolism in the liver. Previous studies have demonstrated that it stimulates lipolysis, energy expenditure and thermogenesis. There is evidence that capsaicin stimulates resting energy expenditure, lipid mobilization and fat oxidation. It has also been found that ingestion after a glucose load promotes glucose consumption in young healthy males. This study will determine if the same effects are seen in young healthy females over the course of a normal oestrous cycle. The results of this study will then allow for translation to a pre-diabetic population to use capsaicin to augment diet and exercise to manage weight loss.
Interventions
Arm A
Intervention type: Dietary Supplement
Intervention name: Capsaicin
Intervention description: 475mg of Capsicum annum fruit powder containing 2.375mg of capsaicin in a capsule. One capsule will be given for consumption 45 minutes after a 90g glucose in the form of a gel has been ingested. The dose is the contents of one capsule from the manufacturer transferred to an unidentifiable capsule as per the placebo. The capsules are approved, health store/supermarket retail products manufactured i
Arm A Intervention type: Dietary Supplement Intervention name: Capsaicin Intervention description: 475mg of Capsicum annum fruit powder containing 2.375mg of capsaicin in a capsule. One capsule will be given for consumption 45 minutes after a 90g glucose in the form of a gel has been ingested. The dose is the contents of one capsule from the manufacturer transferred to an unidentifiable capsule as per the placebo. The capsules are approved, health store/supermarket retail products manufactured in Australia by Nature’s Sunshine Products of Australia Pty. Ltd. The intervention will be given on four individual days each one week apart in the presence of the researher.
Sponsors
La Trobe university
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy with no medical conditions (no diagnosed medical conditions that require the person to take prescription medication) To eliminate different hormone patterns or altered carbohydrate metabolism that has been seen in disease states (such as diabetes), which ultimately could affect the final results. 2. Must be available for morning testing (up to 5 hours) on four individual days one week apart to cover the average oestrous cycle 3. Willingness to fast overnight. 4. Adult females with healthy BMI (18.5 -24.9 kg/m2) BMI is used to estimate the amount of fat and gives a healthy weight range related to individual height. To minimize any underlying metabolic disorders 5. Ability to tolerate oral ingestion of capsaicin determined by previous ingestion of capsicum containing foods/supplements.
Exclusion criteria
1. Diagnosis of any medical conditions Disease states such as diabetes can alter participants’ metabolism. This would affect the researcher’s ability to determine the full effect capsaicin has on lipid and carbohydrate metabolism 2. Must be able to understand and comprehend instructions given to them in English, as determined by the researcher. There will not be translator available to assist participants during testing. 3. Taking any regular medications for a diagnosed medical condition Metabolism (lipid and carbohydrate) can be affected by different medications and could interfere with obtaining accurate results. 4. Inability to tolerate or experience of adverse effects from capsaicin or capsaicin containing products Participants who cannot tolerate or experience adverse effects from capsaicin are excluded from the experiment. 5. Participants who have never ingested capsaicin or capsaicin containing product will be excluded from the experiment
Outcome results
None listed