None listed
Conditions
Brief summary
This project aims to determine the effect of exercise intensity on brain recovery biomarkers in stroke survivors who have or have had mobility impairments after stroke and healthy age and sex-matched controls. We will measure post-exercise changes in the following biomarkers: salivary biomarkers of stress and inflammation cortico-excitability using Transcranial Magnetic Stimulation (TMS)
Interventions
Each participant will perform two exercise sessions one 21 minutes session of moderate intensity aerobic interval training i.e. 40-60% of Heart Rate Reserve and one high intensity exercise i.e. 70-85% HRR. Intervals are 90 seconds with an active rest period of at low intensity (~20-30% HRR). The session will take place face-to face in a research clinic. There will be a wash out period between exercise sessions of at least 60 minutes.
The order of the sessions will be randomised.
Session w
Each participant will perform two exercise sessions one 21 minutes session of moderate intensity aerobic interval training i.e. 40-60% of Heart Rate Reserve and one high intensity exercise i.e. 70-85% HRR. Intervals are 90 seconds with an active rest period of at low intensity (~20-30% HRR). The session will take place face-to face in a research clinic. There will be a wash out period between exercise sessions of at least 60 minutes. The order of the sessions will be randomised. Session will be supervised by a physiotherapist and a trained clinical research assistant. Exercise will be performed on a recumbent bike and will be precede by a 5 minute warm up and after completion participants will perform a 3-5 minute cool down. The warm up and cool down will be performed on the exercise equipment i.e. recumbent bike, cycle ergometer or treadmill, in which the session will be performed. The choice of exercise equipment will be based on availability and preference of the participant and will consistent for both sessions.
Sponsors
Sharon Kramer
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
21 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Eligibility criteria: Adult (>21 years of age) stroke survivors Are eligible for Medicare Clinically diagnosed with first ever ischaemic/haemorrhagic stroke Stroke onset between 1 – 12 months ago at enrolment. Medically stable No contra-indications to perform moderate to high-intensity exercise. Able to follow instructions and give written consent Adult healthy age and sex matched controls (>21 years of age) Are eligible for Medicare. Relatively healthy individuals with no contraindications to perform exercise
Exclusion criteria
Exclusion criteria: Severe cardiac comorbidities such as unstable angina, severe aortic stenosis etc. Neurological comorbidities other than stroke such as Parkinson’s disease, Multiple Sclerosis etc. Severe musculoskeletal comorbidities Severe respiratory comorbidities such as severe COPD, pulmonary fibrosis Pacemaker implant Patients or healthy individuals with metal ferromagnetic objects implanted in the head or neck area.
Outcome results
None listed