None listed
Conditions
Brief summary
This study aims to understand the optimal ways to implement lung cancer CT screening in Australian, and specifically to research the best ways to recruit and undertake lung cancer screening in at risk people from a range of geographic and socioeconomic communities Who is it for? You may be eligible to join this study if you are aged between 50 and 80 years old, and have risk factors for developing lung cancer Study details All participants who meet the eligibility criteria in this study will have a low dose CT chest scan and complete a questionnaire about possible risk factors. Participants will be followed-up post-scan annually for 10 years to assess risk of developing lung cancer and quality of life. It is hoped that this research project will help identify how to optimally invite people at risk for lung cancer screening.
Interventions
Low dose CT chest scan screening for people at high risk of lung cancer who meet screening eligibility criteria.
A low dose CT scan which usually has a radiation dose of about 1.5mSv will be provided by registered Medical Imaging Providers by their Radiographers and Radiologists in accordance to their Standard Operating Procedures. The dose of radiation will be monitored for each scan. The scan does not involve contrast and may take 10-15 minutes to complete.
While there is no specific bio-s
Low dose CT chest scan screening for people at high risk of lung cancer who meet screening eligibility criteria. A low dose CT scan which usually has a radiation dose of about 1.5mSv will be provided by registered Medical Imaging Providers by their Radiographers and Radiologists in accordance to their Standard Operating Procedures. The dose of radiation will be monitored for each scan. The scan does not involve contrast and may take 10-15 minutes to complete. While there is no specific bio-specimen donation requested in the ALST trial, any Trial Participants who live in or near the Metro North HHS and local area may choose to be invited for donation to the existing The Prince Charles Hospital Lung Bank (Ethics approval: HREC 17/QPCH/54).
Sponsors
The University of Queensland
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Male and Female Aged 50-80 years. ECOG performance status of 0 or 1 Capable of providing, informed consent for screening procedures (low dose spiral CT) Meets the PLCOm2012 criteria with risk score equal to or greater than 1.51% over 6 years, aged 55 to 74 years, or Australian Medical Services Committee (MSAC) criteria aged 50 to 70 years who have a history of cigarette smoking of at least 30 pack-years, and, if former smokers, quit within the previous 10 years, or US Preventative Services Task Force (USPSTF) criteria of Adults aged 50 to 80 years who have a 20 pack-year smoking history and currently smoke or quit within the past 15 years
Exclusion criteria
Clinical symptoms suspicious for lung cancer e.g., haemoptysis, chest pain, weight loss Any medical condition, such as severe heart disease (e.g., unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, home oxygen therapy, bleeding disorder, that in the opinion of the investigator could jeopardize the subject’s safety during participation in the study or unlikely to benefit from screening due to shortened life-expectancy from the co-morbidities. Have been previously diagnosed with lung cancer. Have had other non-curatively treated cancer outside the lung. Pregnancy. Pneumonia or bronchitis requiring antibiotic treatment within the last 12 weeks. Unwilling to have a spiral chest CT. Chest CT within 2 years Does not fit into CT scanner table due to gross obesity. Cannot lie on CT scanning table on the back with arms over the head. Received chemotherapy or cytotoxic drugs within the last 6 months. Unwilling to provide consent.
Outcome results
None listed