None listed
Conditions
Brief summary
An 8-week randomized feasibility trial will be conducted to investigate motor and non-motor responses to high-intensity interval training utilizing a combined arm and leg ergometer in individuals with mild to moderate Parkinson's disease (PD). control group will receive usual care. Primary hypothesis High-intensity combined arm and leg ergometry added to usual care will lead to increases in habitual gait speed in people with PD compared to usual care.
Interventions
A randomized controlled feasibility trial will be conducted to investigate the effects of high intensity interval training (HIIT) in a novel mode of combined arm and leg ergometry, (Rogue Echo) (Rogue Fitness, Columbus, Ohio, U.S.A), on physiological and functional outcomes in individuals with mild to moderate Parkinsons disease (PD). The trial will run for 8 weeks with 24 (1 hour) sessions in total for the intervention group, excluding 4 weekly baseline assessment sessions and two weekly reasse
A randomized controlled feasibility trial will be conducted to investigate the effects of high intensity interval training (HIIT) in a novel mode of combined arm and leg ergometry, (Rogue Echo) (Rogue Fitness, Columbus, Ohio, U.S.A), on physiological and functional outcomes in individuals with mild to moderate Parkinsons disease (PD). The trial will run for 8 weeks with 24 (1 hour) sessions in total for the intervention group, excluding 4 weekly baseline assessment sessions and two weekly reassessment session at conclusion of the intervention in both groups for total of 14 weeks. Dose exposure intensities will be individualized from initial baseline maximal oxygen consumption, anaerobic capacity tests and utilizing Borg (6-20) rate of perceived exertion scales. Eighty-five (85) % of mean maximal power obtained during a maximal anaerobic capacity test performed on the Rogue Echo will be used to prescribe the workload intensity during the intervention process. A total of 8 rounds with work to rest ratios of 1:3 minute will be implemented. The intervention will consist of HIIT performed on a specialized cycle ergometer that consists of a normal lower limb cycle that has handles for the upper limbs that the participant push and pulls in a liner motion. Sessions are approximately 1 hour within small groups of participants (1-2). The intervention will be added to usual care. Secondary outcomes will also include adherence to both exercise intensity and modality. This will be assessed by measuring time spent at target workload intensity and adherence to volume and duration of exposure. An addition to the assessment days (day 3 & 4) includes an acute exposure to the HIIT intervention focusing either arm only or a combined arm and leg ergometry on the Rogue Echo. This component aims to isolate and compare the physiological effect differences of lower versus combined upper and lower limb exercise. During these sessions, pure physiological parameters such as blood pressure, heart rate, and VO2 differences will be assessed and compared between groups. Additionally, participants' perceptual responses will be evaluated using the Borg (6-20) scale alongside affective responses assessed with the Feelings Scale. All assessments and interventions will be implemented face to face at the University of Sydney, Susan Wakil health building research spaces, Camperdown, NSW, Australia. Assessment days will vary from a minimum of one to a maximum of three hours (1-3). All assessments and interventions will be implemented by accredited exercise physiologists.
Sponsors
University of Sydney
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Diagnosis of idiopathic PD with a severity of 3 or less on the Modified Hoehn and Yahr scale.
Exclusion criteria
Exclusionary criteria: A rating greater than 3 on the Modified Hoehn and Yahr scale or no physician diagnosis of PD. Non-community dwelling residential status. Currently participating in greater than 150 minutes of moderate- to high-intensity exercise training (defined as aerobic, resistance or high-intensity interval training) per week. Individuals with secondary PD or other progressive neurological disease. The presence of deep brain stimulation (DBS) devices. Unstable medical conditions that would preclude individuals from exercising. Unstable coronary or cerebral artery disease (2+ TIAs in past year, unstable angina), recent MI or stroke (within the past 6 months) symptomatic peripheral vascular or other medical conditions precluding the planned exercise: e.g., heart failure with reduced ejection fraction (HFrEF), untreated known aneurysms, symptomatic hernias, uncontrolled or malignant cardiac arrythmias, moderate-to-severe pulmonary disease, Stage 5 renal disease or permanent non-ambulatory status, proliferative retinopathy or recent ocular surgery (within 3 months), a diagnosis of dementia or significant cognitive impairment as defined by a score less than 1719 on the Montreal Cognitive Assessment (MoCA) indicating difficulties in aspects such as memory, communication, and ability to focus and comprehend exercise instructions, follow the exercise protocol, and provide informed consent,., medications that could indicate treatment of dementia, medications that could affect neurological function and safety including but not limited to anti-psychotics, sedatives-hypnotics or narcotic analgesics, as determined by the study physician assessment.
Outcome results
None listed