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Effects of chronic Tai Chi Chuan and aerobic exercise interventions on motor and neurocognitive performance in early-stage Parkinson’s disease

Effects of chronic Tai Chi Chuan and aerobic exercise interventions on motor and neurocognitive performance in early-stage Parkinson’s disease

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12623001250628
Enrollment
43
Registered
2023-12-01
Start date
2020-01-14
Completion date
2022-12-20
Last updated
2023-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

the primary objective of the present study was to investigate and compare the effects of 12 weeks of Tai Chi Chuan and aerobic exercise on the neurocognitive functioning of the WM in patients with PD, since these two types of exercise involve distinct characteristics in terms of physiological demand (cardiorespiratory vs. muscular fitness) and cognitive load (single vs. dual tasks) during training. Change in motor-symptom severity as a result of the two interventions was the secondary outcome of the study . We hypothesized that chronic Tai Chi Chuan and aerobic exercise interventions would improve motor and neurocognitive functioning in PD patients. We also expected that the two exercise modes would have varying degrees of benefits, with Tai Chi Chuan predominately enhancing motor performance and aerobic exercise favoring neurocognitive performance to a greater extent.

Interventions

The 12-week aerobic exercise program consisted of a 30 min training session performed three times weekly on a recumbent stationary bicycle. Before every training session, each participant’s resting heart rate was measured to calculate their heart rate reserve (HRR). The aerobic exercise protocol included a 4 min warm-up phase, followed by 24 min of moderate-to-high-intensity interval aerobic training (eight cycles of 1 min with 70–75% HRR followed by a 2 min active recovery period [target RPE: 9

The 12-week aerobic exercise program consisted of a 30 min training session performed three times weekly on a recumbent stationary bicycle. Before every training session, each participant’s resting heart rate was measured to calculate their heart rate reserve (HRR). The aerobic exercise protocol included a 4 min warm-up phase, followed by 24 min of moderate-to-high-intensity interval aerobic training (eight cycles of 1 min with 70–75% HRR followed by a 2 min active recovery period [target RPE: 9–11]), and finally a 2 min cool-down period. The target HR was monitored using a Polar HR monitor (RS800CX, Polar Electro Oy, Kempele, Finland). The participants were verbally encouraged to achieve the appropriate intensity for each phase, and they exercised under the medical supervision of a physical therapist. The 12-week Tai Chi Chuan program comprised two 60 min sessions per week, and each session was led by a Tai Chi Chuan master with over 20 years of experience. The session consisted of a warm-up and the main exercise, and all movements were adapted from the Yang-style short form. The warm-up session included the bear swing, the Tai Chi walk, and a range of motion exercises. It focused on kinesthetic awareness, mind–body preparation, and stretching and incorporated high-amplitude and diagonal movements. The main exercise phase focused on weight-shifting skills; bilateral coordination; and postural control, including preparation, beginning, roll back, ward off, push, press, and single whip elements. The Tai Chi master first demonstrated a movement, then deconstructed it and taught it step by step. To ensure accuracy, the master corrected each participant’s movements. One to two new movements were taught in each session, and the entire sequence of learned postures was practiced together to reinforce the connection between the mental tracking and the physical aspect. In addition to the postures, the participants were taught other essential elements of Tai Chi Chuan, such as body orientation, breathing, and relaxation. 1. The aerobic exercise will be run individually and the Tai Chi Chuan will be a group class with the ratio of 1:5~1:10 (5~10 participants with 1 leader) 2. Each participant will only attend in one group. 3. Attendance record will be done in each intervention to monitor the adherence. Each participant will only attend in one group, one program.

Sponsors

National Science and Technology Council
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

The clinical inclusion criteria were as follows: (a) a confirmed diagnosis of PD by neurologists at the Neurology Department of one of the above hospitals, and a medically stable status; (b) a modified Hoehn & Yahr score between 1 and 2, indicating early-stage PD; (c) the absence of any major comorbidities, such as dementia or depression; (d) no brain abnormalities (e.g., stroke or malignant brain tumor) on structural MRI scans; (e) age between 50 and 80 years; (f) confirmed ability to complete exercise training, as determined using the Physical Activity Readiness Questionnaire (PAR-Q) and by their treating neurologist; and (g) willingness to be randomly assigned to one of the exercise intervention groups or the control group.

Exclusion criteria

Exclusion criteria were as follows: (a) a history of any neurological disease other than PD; (b) a diagnosis of dementia based on a MMSE or Montreal Cognitive Assessment (MoCA) score of < 24; (c) moderate or significant depression, as assessed based on a score of > 16 for the Beck Depression Inventory-II (BDI-II); (d) use of medication that interferes with cognition, alertness, or attention; or (e) previous or current participation in an exercise training program.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026