None listed
Conditions
Brief summary
The purpose of this study is to assess reliability and validity of ultrasound (US) to quantify muscle content for use in a randomised clinical trial assessing interventions. Methods: Thirty volunteer participants will undergo assessments of muscle and subcutaneous fat thickness using US and magnetic resonance imaging (MRI). Independent raters will perform two serial US measures using US. Test–retest and inter-rater reliability will be assessed using intraclass correlation coefficient (ICC). Agreement between US and MRI will be assessed with Bland–Altman analysis. Discussion We will validate the use of US using upper and lower body landmarks against gold standard MRI measurements for muscle and fat assessment.
Interventions
The participants will be asked to wear or bring shorts and a t shirt and will be expected to be in the clinical research area for 2 hours in total, on one occasion. Participants will be landmarked at the right mid-bicep, right and left mid-thigh and 2/3 thigh. Researchers will use the Phillips Lumify Ultrasound portable ultrasound machine with the B-mode L12-4 linear array transducer. The MRI and US measurements will be taken on the same occasion. Trained staff at the Centre for Advanced MRI wi
The participants will be asked to wear or bring shorts and a t shirt and will be expected to be in the clinical research area for 2 hours in total, on one occasion. Participants will be landmarked at the right mid-bicep, right and left mid-thigh and 2/3 thigh. Researchers will use the Phillips Lumify Ultrasound portable ultrasound machine with the B-mode L12-4 linear array transducer. The MRI and US measurements will be taken on the same occasion. Trained staff at the Centre for Advanced MRI will conduct the take the MRI measurements. Three images will be taken at each site. The US images will be taken by research dietitians who have undergone training. There is only one ultrasound method.
Sponsors
The University of Auckland
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Adults, healthy
Exclusion criteria
Diseases and conditions affecting muscles (structure or function), musculoskeletal injuries of the lower limb and pathologies including fractures, surgical procedures, cancer, or neurological disorders, and any issue that is a contraindication for MRI will also be excluded. Examples include cardiac implant, history of welding injury, cochlear or hearing implant, prosthetic limb, magnetic dental implant.
Outcome results
None listed