None listed
Conditions
Brief summary
BARISTA is a prospective, multi-centre bacterial genomics study of invasive Staphylococcus aureus infections that is currently recruiting the Austin Hospital and Royal Melbourne Hospital in Melbourne. Adult patients admitted for a monomicrobial sterile site infection (eg. blood, bone, or joint) are included, with up to a year follow-up. The study collects all clinical samples with growth of S. aureus (blood cultures but also bone, muscle, joint), and samples from recurrent infections within a year. Nasal swabs are collected at enrolment and after 6 and 12 months and in case of recurrence. EDTA blood is collected to extract cell-free DNA (cf-DNA).
Interventions
Invasive S. aureus infection (at least 1 sterile sample with growth of S. aureus [e.g. blood, valve, bone]) admitted at Austin and Royal Melbourne Hospitals in Melbourne, Victoria
Following samples are collected:
1. At enrolment and during the initial admission:
- all clinical samples with growth of S. aureus: blood cultures, tissue biopsies (e.g. bone, muscle), body liquids (e.g. joint fluid), pus from abscesses. These samples are already collected for clinical reasons, no additional interventi
Invasive S. aureus infection (at least 1 sterile sample with growth of S. aureus [e.g. blood, valve, bone]) admitted at Austin and Royal Melbourne Hospitals in Melbourne, Victoria Following samples are collected: 1. At enrolment and during the initial admission: - all clinical samples with growth of S. aureus: blood cultures, tissue biopsies (e.g. bone, muscle), body liquids (e.g. joint fluid), pus from abscesses. These samples are already collected for clinical reasons, no additional intervention required - a nasal swab (collected by a registered nurse) - a 9 ml blood sample at enrolment, after 3 days and after 7 days (collected by a registered nurse) 2. At follow-up at 6 and 12 months after enrolment: - nasal swab (self collection) 3. At infection recurrence within 12 months: - all clinical samples with growth of S. aureus: blood cultures, tissue biopsies (e.g. bone, muscle), body liquids (e.g. joint fluid), pus from abscesses. These samples are already collected for clinical reasons, no additional intervention required - a nasal swab (collected by a registered nurse) - a 9 ml blood sample at enrolment, after 3 days and after 7 days (collected by a registered nurse)
Sponsors
University of Melbourne
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Age greater or equal to 18 years • Admitted to a participating centre • Invasive S. aureus infection (at least 1 sterile sample with growth of S. aureus [e.g. blood, valve, bone])
Exclusion criteria
• Polymicrobial infection at time of inclusion • Treating team deems enrolment in the study is not in the best interest of the patient • Death is deemed to be imminent and inevitable within the next 48 hours
Outcome results
None listed