None listed
Conditions
Brief summary
Nasally inhaled isopropyl alcohol (IPA) is readily available and an easy-to-administer intervention, that has been shown to reduce nausea and vomiting in patients presenting to the emergency department. The purpose of this trial is to determine the effectiveness of inhaling IPA in reducing nausea and vomiting in the self-ventilating ICU patients. It is hypothesised that nasally inhaled IPA reduces the requirement for intravenous ondansetron in critically ill patients with nausea and vomiting.
Interventions
Intervention: The participants will be supplied with three 70% Isopropyl Alcohol-soaked swabs (Briemar Nominees Pty Ltd, Victoria, Australia). The ICU nurse or clinician will educate the participant to hold the swab 1 to 2 cm from the nares and encourage them to inhale deeply through the nose as frequently as required to achieve nausea relief. Three new pads will be supplied every 15 minutes if required over the 60 minute intervention period. (i.e. up to a total of 12 swabs over the course of 60
Intervention: The participants will be supplied with three 70% Isopropyl Alcohol-soaked swabs (Briemar Nominees Pty Ltd, Victoria, Australia). The ICU nurse or clinician will educate the participant to hold the swab 1 to 2 cm from the nares and encourage them to inhale deeply through the nose as frequently as required to achieve nausea relief. Three new pads will be supplied every 15 minutes if required over the 60 minute intervention period. (i.e. up to a total of 12 swabs over the course of 60 minutes). Participants will be asked to rate their nausea on nausea VAS scoring sheet at 5, 15, 30, 45, and 60 minutes post-intervention. Nursing staff will also record the number of vomiting or dry retching episodes observed in the 60 minute period post-intervention. At 30 minutes and 60 minutes post-intervention, a 5-point Likert scale to measure overall satisfaction with the therapy will be recorded by the ICU nurse or clinician.
Sponsors
Royal Adelaide Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients admitted to the Intensive Care Unit at the Royal Adelaide Hospital will be recruited if they meet all of the following inclusion Criteria: 1. Reports symptom of nausea or witnessed episode of vomiting / dry retching 2. Would be initiated on PONV protocol management 3. Aged 18 or above 4. Self-ventilating
Exclusion criteria
Exclusion Criteria: 1. Allergy to isopropyl alcohol 2. Allergy to ondansetron 3. Inability to breathe through the nose 4. Inability to give informed consent 5. Mental or physical state precluding accurate assessment of nausea/ satisfaction scores 6. Administration of antiemetic medication within the preceding 8 hours 7. Administration of medication known to produce nausea when exposed to alcohol within the preceding 24 hours (e.g. Metronidazole, Disulfiram, Tinidazole, Trimethoprim-Sulfamethoxazole) 8. Symptoms of nausea or vomiting for > 24 hours 9. Pregnancy
Outcome results
None listed