Comparison clinical sensitivity and specificity of self-collected vs practitioner-collected samples from patients attending for colposcopy.

The study will ask participants to take two self-collected vaginal samples using two different devices and compare them against the standard of care clinician-collected specimen from the cervix for the detection of Human Papillomavirus (HPV) using any colposcopy biopsy findings as the reference for sensitivity and specificity for cervical disease. Particiapnts who have been referred to colposcopy would not be routinely tested for HPV as this is a risk stratification rather than diagnostic test. The two devices are the Copan FLOQSwab and the Rovers Viba-brush. The Copan FLOQSwab is a thin swab (similar to the swabs used for collection of a sample for COVID19 PCR testing. The Viba-brush is a simpler version of the Evalyn brush which is a device designed specifically for self-collection for HPV-based cervical screening and consists of a head with a soft plastic broom-like head on a plastic shaft. Both are commonly used in self-collection and have regulatory approval for self-collection for HPV-based cervical screening and collection would take less than one minute for each device. Both devices will be collected at the same time in a private space while waiting for the patient's colposcopy appointment, Collection with both devices would be completed is less than five minutes total time .