None listed
Conditions
Brief summary
We plan to explore the feasibility of providing human albumin infusions in the home setting by community nurses.
Interventions
The intervention involves the administration of intravenous human albumin weekly at home rather than in the hospital setting. Each participant will receive an intravenous infusion of 20% Home Albumin in 100mL vials at a dose of 40g twice weekly for the first two weeks, and 40g weekly thereafter for the study duration (six months) administered by South Australian Community Care Nurses.
Sponsors
Flinders Medical Centre
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Age >18 years with capacity to consent for treatment • Patient with mild cognitive impairment, at treating doctor and/or PI’s discretion • Under active management by FMC Hepatology and Transplant Medicine Unit • Patients with decompensated liver disease (Child Pugh Score B or C) with related symptom of: • Ascites or hepatic hydrothorax with or without intolerance to diuretics • HRS or acute kidney injury (AKI) • Persistent peripheral oedema • Severe hypoalbuminaemia <25g/L.
Exclusion criteria
• Patients not managed by the FMC Hepatology Unit • Unsafe environments for conducting home visits • Patients with a diagnosis of heart failure • Patients with chronic kidney disease • Patients with pulmonary hypertension • Patients who are difficult to cannulate (previously required medical officer assistance or multiple attempts for previous cannulation) • Patients requiring weekly Large Volume Paracentesis • Patients with severe hepatic encephalopathy or without cognitive capacity.
Outcome results
None listed