None listed
Conditions
Brief summary
This study aims to determine the most effective and long-lasting pain relief method for post-operative analgesia in kidney donor and recipient patients in kidney transplantation programme with the least invasive and least drug administration. For this reason, it is planned to perform Quadratus lumborum plane block (QLB) in a group of patients who will be kidney donors and kidney recipients in kidney transplantation and who meet the ASA1-3 risk classification between the ages of 18-70 years, and to administer intravenous pain medication without block in another group. It is planned to include at least 84 patients in the Quadratus lumborum plan block (QLB) and Intravenous Analgesia group (IVA) without gender discrimination. Postoperative Sedation-Agitation assessment and NRS (numeric pain scale) at 1st hour, 2nd, 6th, 12th and 24th hours, as well as possible side effects such as nausea, vomiting, shoulder pain, respiratory depression, bradycardia and hypotension, total amount of opioid analgesics consumed within 24 hours and duration of hospital stay will be observed and recorded.
Interventions
Under general anaesthesia, quadratus lumborum block with 20 ml of 0.25% bupivacaine will be applied to the side where the surgical incision will be made under ultrasound guidance to the recipient and donor patients included in the kidney transplant surgery programme under elective conditions.
- plane block ultrasound-guided intra-abdominal injection into the appropriate anatomical area
- the injection will be administered immediately after general anaesthesia and intubation of the patient
- to
Under general anaesthesia, quadratus lumborum block with 20 ml of 0.25% bupivacaine will be applied to the side where the surgical incision will be made under ultrasound guidance to the recipient and donor patients included in the kidney transplant surgery programme under elective conditions. - plane block ultrasound-guided intra-abdominal injection into the appropriate anatomical area - the injection will be administered immediately after general anaesthesia and intubation of the patient - to monitor compliance with the intervention The medical files and laboratory blood tests of the patients will be examined to determine whether there are any contraindications to the intervention (patients will be excluded in case of bleeding diathesis such as intra-abdominal fluid accumulation, cystic formation, INR > 2 or thrombocytopenia). Blood pressure and heart rate values of the patient and the amount of fentanyl consumed will be recorded throughout the surgery. The level of sedation-agitation will be evaluated during extubation at the end of surgery. In the postoperative period, blood pressure, heart rate, pain scoring and the amount of opioid analgesic consumed will be recorded by the anaesthesiologist in the general surgery organ transplant unit and the general surgery specialist and nurses in the organ transplant service at the 1st, 2nd, 6th, 12th, and 24th hours. The patient's satisfaction level will be evaluated and recorded 24 hours after the operation.
Sponsors
TR HSU Diyarbakir Gazi Yasargil TRH
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Patients aged 18-70 years, ASA I-III, being a volunteer kidney recipient or volunteer donor in a kidney transplant programme under general anaesthesia
Exclusion criteria
Age <18 years or > 70 years ASA >III body mass index (BMI) > 35 kg/m2 known allergy to local anaesthetics or parasetamol/tramadol presence of preoperative chronic pain ppresence of accumulated fluid or cystic formation in the abdomenresence of coagulopathy those who are unable to give written consent
Outcome results
None listed