Comparison of early versus late initiation of trophic feeding in preterm infants.

Comparison of early versus late initiation of trophic feeding in preterm infants on duration of stay in high dependency unit: a non-randomized clinical trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12623000752662

Enrollment

240

Registered

2023-07-11

Start date

2023-07-30

Completion date

2023-10-30

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

COMPARISON OF EARLY VERSUS LATE INITIATION OF TROPHIC FEEDING IN PRETERM INFANT: Preterm infant is defined by WHO as an infant delivered before 37 weeks of gestation. Nutrition in the postnatal period is essential to achieve optimal growth and development of preterm infants. The timing of introduction of feeds and the rate of advancement of those feeds in preterm infants are however controversial. Enteral feed aids in the development of gut in preterm infants and lowers the risk of infections and sepsis. Trophic feeding is the practice of feeding small amounts of enteral feeds to preterm infants to stimulate the enzyme activity, hormone release, blood flow, motility and microbial flora of their immature gastrointestinal tract. HYPOTHESIS: Early initiation of Trophic feeding(<48hrs postnatal age) as compared to Late(>72hrs postnatal age) of preterm infants is associated with less duration of stay in neonatal unit and improved survival of preterm infants. STUDY DESIGN: Non randomized clinical trial. STUDY PURPOSE To assess improved preterm survival with early trophic feed introduction from less duration of hospital stay.

Interventions

Early trophic feed initiation will be done according to birth date admitted on their 1st or 2nd day of life comprising of expressed breast milk given at <48 hours postntal age of preterm infant every 2 hourly 1 to 2 ml in amount with a total of 12 feeds in 24 hours. Increasing the amount of feed daily by 1-2 ml till the end of stay or when neonate is able to take full oral feeds.

Study design

Allocation

Non-randomised trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

1 Days to 2 Days

Healthy volunteers

Inclusion criteria

Preterm 28 weeks to 36 weeks gestation. Birth weight 1000 to 2500 g Age<3 days postnatal age at time of admission

Exclusion criteria

Preterm infants with major congenital anomaly. Preterm infant on inotropic drug support. Preterm infants with severe respiratory distress.

Outcome results