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Chiropractic adjustment and brain, eyes and heart activity

Effects of chiropractic adjustments on autonomic nervous system function in adults with subclinical spinal pain: A pilot randomized controlled trial assessing prefrontal cortex activity, pupil changes, and heart rate variability.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12623000725662
Enrollment
24
Registered
2023-07-05
Start date
2024-02-05
Completion date
2024-03-04
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Chiropractic adjustments have a positive impact on various aspects of central and autonomic nervous system (ANS) function, in particular, a single session of chiropractic adjustments has been shown to alter pre-frontal cortex (PFC). This proposed pilot study aims to evaluate the feasibility of conducting a randomised controlled trial exploring the effects of chiropractic adjustments on autonomic nervous system by measuring prefrontal cortex activity during stress, pupil diameter and heart rate variability.

Interventions

Chiropractic Intervention: The entire spine and both sacroiliac joints will be assessed for vertebral subluxations and adjusted where deemed necessary by an experienced chiropractor of minimum 10 years’ experience. The clinical indicators of vertebral subluxations include tenderness to palpation of the relevant joints, manual palpation for restricted intersegmental range of motion, palpable asymmetric intervertebral muscle tension, and any abnormal or blocked joint play and end-feel of the join

Chiropractic Intervention: The entire spine and both sacroiliac joints will be assessed for vertebral subluxations and adjusted where deemed necessary by an experienced chiropractor of minimum 10 years’ experience. The clinical indicators of vertebral subluxations include tenderness to palpation of the relevant joints, manual palpation for restricted intersegmental range of motion, palpable asymmetric intervertebral muscle tension, and any abnormal or blocked joint play and end-feel of the joints. These clinical indicators are routinely used by chiropractors when analysing the spine and have previously been shown to be reliable for the identification of vertebral subluxations when used as a multidimensional battery of tests. Any chiropractic spinal adjustments will involve a high-velocity low-amplitude thrust, a standard chiropractic technique, to sites deemed to have vertebral subluxations as identified using the indicators above. These adjusting techniques have been previously used in studies that have investigated neurophysiological effects of spinal adjustments [for review see Haavik et al., 2021]. The chiropractic intervention will be delivered in a single session and will take around 10 minutes. Before and after the chiropractic or control intervention, participants will perform alternating trials of immersing their hands in cold water and performing a mental arithmetic task (Maastricht Acute Stress Test).

Sponsors

New Zealand College of Chiropractic
Lead SponsorOther

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

Individuals aged between 18 and 50 years with subclinical spinal pain (SCSP) will be recruited. SCSP refers to individuals who have a previous history of recurring spinal (e.g., neck, mid-back or low back) pain, ache, or tension, that is not always present, that they have not yet sought any treatment for, and may or may not be accompanied with a history of spinal injury. The participants will be included if they have no or mild symptoms on the day of the experiment (i.e., less than 3/10 on the numeric pain rating scale) and have not received any chiropractic adjustment or any other manual therapy in the past two weeks of their data collection session.

Exclusion criteria

- Diagnosed dysautonomia and Raynaud's disease. - Have any contraindications to chiropractic adjustments (such as a history of recent spinal fractures; inflammatory disease; or recent cancer). - Have any damage to your eyes (such as coloboma or oculomotor palsy). - Have cardiovascular diseases, hypertension (including fully controlled hypertension), severe physical illnesses (e.g., Fibromyalgia) or endocrine disorders. - Have any pre-existing neurophysiological or psychological conditions. - Are currently managing any acute or chronic pain conditions. - Are taking any medications known to affect the HPA axis such as corticosteroids. - Vape or smoke cigarette (more than 10 smokes/day). - Are pregnant.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026