None listed
Conditions
Brief summary
The National TB Prevalence Survey of Timor Leste is a cross-sectional randomised cluster survey to assess the prevalence of pulmonary tuberculosis in persons aged 15 years and older in Timor Leste. Survey participants will be screened for tuberculosis using a combination of symptom screening and chest x-ray with bacteriological testing by rapid molecular test and mycobacterial culture. Results of the survey will be used to update estimates of Timor Leste’s burden of tuberculosis, including incidence, prevalence and mortality.
Interventions
Participants will be screened for pulmonary tuberculosis at a single point in time. Screening will consist of a chest x-ray which will be automatically assessed for evidence of pulmonary tuberculosis by the CAD4TB software platform, and a short symptom screening interview to identify the presence of possible TB symptoms (cough >2 weeks, fever, weight loss, night sweats).
Participants who have radiological evidence of pulmonary tuberculosis (CAD4TB propensity score >60) and/or one or more TB sy
Participants will be screened for pulmonary tuberculosis at a single point in time. Screening will consist of a chest x-ray which will be automatically assessed for evidence of pulmonary tuberculosis by the CAD4TB software platform, and a short symptom screening interview to identify the presence of possible TB symptoms (cough >2 weeks, fever, weight loss, night sweats). Participants who have radiological evidence of pulmonary tuberculosis (CAD4TB propensity score >60) and/or one or more TB symptoms will be eligible for sputum collection. These participants will be asked to provide two sputum samples collected >1 hour apart. Sputum samples will be tested by GeneXpert Ultra, with those testing positive for TB, going on for mycobacterium liquid culture confirmatory testing. Any participant in whom symptoms or radiological evidence of TB is identified, will be referred to their local community health centre for further investigation and treatment. The complete screening process takes approximately 10-20 minutes.
Sponsors
Menzies School of Health Research
Eligibility
Sex/Gender
All
Age
15 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Persons aged 15 years and older, who have been living in a randomly selected survey cluster for at least two weeks prior to screening, and who are able to provide signed consent to participate.
Exclusion criteria
Children and adolescents aged less than 15 years of age Not residing in one of the selected survey cluster areas for at least two weeks prior to the survey Residents of congregate settings including boarding schools, college dormitories, correctional facilities and hospital inpatients Unable to provide informed consent to participate in the survey Unable to participate in screening activities due to serious illness or incapacitation
Outcome results
None listed