None listed
Conditions
Brief summary
Age-related increases in reactive oxygen species (ROS) production by skeletal muscle mitochondria have been linked to the failure of exercise responses in aged muscle. These changes limit the efficacy for exercise to maintain or improve muscle health in old age. Interventions that decrease mitochondrial ROS levels may improve the capacity of aged skeletal muscle to respond to exercise. The mitochondria-targeted antioxidant MitoQ is designed to accumulate in mitochondria and decrease ROS. The purpose of this study is to determine the effect of MitoQ supplementation on mitochondrial ROS levels and function and acute exercise responses in skeletal muscle from older individuals. Study hypotheses MitoQ supplementation will increase mitochondrial respiration and decrease mitochondrial ROS levels in skeletal muscle from older individuals. MitoQ supplementation will augment exercise responses in skeletal muscle from older individuals.
Interventions
The study contains two arms: treatment (arm 1) and placebo (arm 2). Participants in arm 1 will consume one MitoQ capsule (containing mitoquinol mesylate equivalent to 20mg mitoquinol) per day orally for 12 weeks. Adherence to the supplement protocol will be monitored via capsule return.
On the day of completion of the 12-week supplementation period, participants in both arms will complete a 20-minute bout of high-intensity interval exercise on a stationary cycle ergometer. Participants will com
The study contains two arms: treatment (arm 1) and placebo (arm 2). Participants in arm 1 will consume one MitoQ capsule (containing mitoquinol mesylate equivalent to 20mg mitoquinol) per day orally for 12 weeks. Adherence to the supplement protocol will be monitored via capsule return. On the day of completion of the 12-week supplementation period, participants in both arms will complete a 20-minute bout of high-intensity interval exercise on a stationary cycle ergometer. Participants will complete 5 x 2-minute bouts of cycling at 80% peak power separated by 2 minutes of cycling at 40% peak power.
Sponsors
Australian Catholic University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Aged 65-80 years, sedentary (complete less than 150 mins of moderate intensity exercise per week and have not performed regular physical activity during the previous 6 months), healthy BMI between 18 and 30 kg/m^2, pass the Exercise and Sports Science Australia (ESSA) pre-exercise screening tool and obtain GP clearance to perform high-intensity exercise.
Exclusion criteria
Acute illness, musculoskeletal, cardiovascular, or neurological disorder that could place the participant at risk of injury or illness resulting from the exercise; coronary heart disease, congestive heart failure, uncontrolled hypertension, diabetes mellitus, bleeding disorder, taking drugs that increase the risk of bleeding or other medications that may impact exercise responses, taking antioxidant supplements in the 6 weeks prior to recruitment, smoking.
Outcome results
None listed