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Managing haemodynamics during conduct of electroconvulsive therapy under general Anaesthesia

Comparison of Pretreatment with Dexmedetomidine and Metoprolol on Attenuation of Hemodynamic Parameters and Emergence during Electroconvulsive Therapy

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12623000539639
Enrollment
60
Registered
2023-05-22
Start date
2022-01-03
Completion date
2022-04-25
Last updated
2023-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study was aimed at interventions that help reduce haemodynamic disturbences during Electroconvulsiive therapy under general Anaesthesia..Study hypothesis was that dexmedetomidine is effective for controllong haemodynamic disturbances following ECT procedure without significantly prolonging the emergence from anaesthesia.. Study was divided into three groups: C,D and M. . Group C included subjects not pretreated with any medicine. Group D: injection dexmedetomidine 0.5 µg/kg diluted in10 ml NaCl intravenously infused over 10 min starting 10 min before induction of anaesthesia. and Group M: injection Metoprolol 1mg diluted in 10 ml NaCl infused in 2 min duration during preoxygenation..

Interventions

All patients undergoing ECT at Combined Military Hospital (CMH) Siialkot were enrolled in this prospective study, by convenient sampling method and were divided into three groups. Group D: injection dexmedetomidine 0.5 µg/kg diluted in10 ml NaCl intravenously infused over 10 min starting 10 minutes before induction of anaesthesia and Group M: injection Metoprolol 1mg diluted in 10 ml NaCl infused over 2 minutes during preoxygenation.

Sponsors

Khalid Mahmood
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

Adults undergoing Electroconvulsive therapy for any psychiatric issue

Exclusion criteria

Children, people in the geriatric range, women who were pregnant, obese people, and people who had known systemic illnesses or allergies were not included.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026