None listed
Conditions
Brief summary
The current study aimed to demonstrate an acute cortisol response following a single high salt meal. While studies to date show an association between high dietary salt-intake over several days and 24-h urinary cortisol, no studies have investigated the acute relationship between salt-intake and cortisol production. The primary aim of our study was to demonstrate salt-induced cortisol production in an acute setting. Our secondary aim was to demonstrate this cortisol production in the absence of an adrenocorticotropic hormone (ACTH) response. We hypothesized that urinary cortisol but not plasma ACTH will increase following a single high-salt meal. To further characterize the role of high salt intake, we measured salivary cortisol, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and blood glucose.
Interventions
Participants consumed one high salt meal (3.82 g; 1529 mg sodium) and one low salt meal (0.02 g; 9 mg sodium) in a randomized cross-over design. The high and low salt meals consisted of tomato soup formulations administered by researchers. There were 6 – 21 days of wash-out between the meals. The trial took place at the Clinical Research Facility at the School of Exercise and Nutrition Sciences, Deakin University and participants visited the facility individually for the trial. Participants atte
Participants consumed one high salt meal (3.82 g; 1529 mg sodium) and one low salt meal (0.02 g; 9 mg sodium) in a randomized cross-over design. The high and low salt meals consisted of tomato soup formulations administered by researchers. There were 6 – 21 days of wash-out between the meals. The trial took place at the Clinical Research Facility at the School of Exercise and Nutrition Sciences, Deakin University and participants visited the facility individually for the trial. Participants attended the research facility from 1200h - 1700h on each day of meal administration. The same treatments were administered to all participants. Adherence was confirmed by observation by researchers who were present during the trial.
Sponsors
Deakin University
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Eligible participants were male or female (18-50 years of age) and not taking medication for blood pressure or diabetes.
Exclusion criteria
Recruits were excluded if they reported any diagnosis with Cushing’s syndrome, any stress or anxiety disorder, depression, any diseases of the adrenal gland, Type 2 diabetes, heart disease, high cholesterol, stroke or cancer or use of medication known to affect cortisol levels. Pregnant or breast-feeding females were excluded, as were participants who recorded resting blood pressure greater than 160/90 mmHg or body mass index (BMI) greater than or equal to 30 kg/m2.
Outcome results
None listed