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Exercise Training After Atrial Fibrillation Ablation

Randomised, Controlled Trial of Exercise Training versus Standard Medical Care on Atrial Fibrillation Recurrence After Ablation in Patients with Symptomatic Atrial Fibrillation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12623000456651
Acronym
EXIT-AF
Enrollment
80
Registered
2023-05-03
Start date
2023-07-24
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will aim to assess the impact of a progressive, structured exercise program in patients with symptomatic AF in a randomised controlled trial. The study intervention will be assessed by the maintenance of sinus rhythm post-ablation, when compared with standard medical care. The primary endpoint of this study is the recurrence of any atrial arrhythmia, off anti-arrhythmic drugs (AADs) in the 18-months post-ablation. We hypothesise that exercise training will reduce arrhythmia recurrence following ablation, compared to standard medical care alone. The key secondary endpoints will include atrial structural remodelling, peak oxygen consumption and AF symptom severity.

Interventions

This progressive exercise interventions builds on successful interventions implemented in different settings by members of the investigator team. Specifically, the intervention includes four phases: Phase 1 (0-3 wks post-ablation, Recovery) will include a remote education component, delivered using online video consultation, that provides guidance on establishing physical activity following an ablation procedure. During these remote consultations, a clinical exercise physiologist will outline

This progressive exercise interventions builds on successful interventions implemented in different settings by members of the investigator team. Specifically, the intervention includes four phases: Phase 1 (0-3 wks post-ablation, Recovery) will include a remote education component, delivered using online video consultation, that provides guidance on establishing physical activity following an ablation procedure. During these remote consultations, a clinical exercise physiologist will outline the evidence-base regarding exercise training for AF patients and will discuss potential barriers to exercise with the patient. The forms of exercise that are suitable for patients with AF will be discussed. The preferences of each patient regarding modes of exercise will be evaluated. Supervised visits will commence from 3 weeks post-ablation. It is anticipated that two 30-minute consultations will be provided within this phase of the intervention. Phase 2 (3-12 wks, Base Training) will target a 10-20% weekly increase in aerobic exercise duration progressing to 210 minutes per week and will include fortnightly supervised visits with an exercise physiologist, with each visit lasting approximately 1 hour. Aerobic exercise will be prescribed within the moderate exercise domain (60-80% heart rate reserve [HRR] or rating of perceived exertion of 6-7 out of 10). Examples of home-based aerobic exercise prescribed within this phase may include outdoor walking, cycling on flat terrain, swimming, dancing or group aerobic exercise. Home-based aerobic exercise will be monitored using a heart rate monitor provided to each patient, and a physical activity diary that can be completed each day. During supervised exercise sessions, participants may be recommended treadmill walking, indoor cycling, rowing, or elliptical exercise, with continuous monitoring using heart rate enabled watches. Attendance at each supervised session will be recorded by study investigators. Phase 3 (12-26 wks, Adaptation) will progressively initiate aerobic interval training activities up to twice per week using a 4x4-min interval structure with a target intensity of 85-90% HRR for each interval. For participants, this means completing four-minute ‘intervals’ at an intensity that requires heavy breathing and an increase in heart rate up to approximately 90% of its maximum, as determined during baseline testing. Participants will repeat these intervals four times, with a three-minute active recovery between each effort. Active recovery may include slow walking or light cycling. Home-based aerobic interval training may be performed on a grass sports pitch, walking trail or hilly area. Supervised visits will remain on a fortnightly frequency. During supervised visits, aerobic interval exercise will be performed on an indoor bike or treadmill. Through phase 3, the target weekly aerobic exercise duration will remain at 210 minutes of moderate to vigorous activity. Attendance at each supervised session will be recorded by study investigators. Finally, in Phase 4 (26-52 wks, Maintenance) will focus on maintenance of aerobic exercise habits, whilst ensuring appropriate progression in intensity in proportion to adaptation of individual physical capacity. During phase 4, supervised visits of 45-60 minutes will decrease in frequency to monthly. However, scheduled televisits of 15-30 minutes will be planned with a clinical exercise physiologist during the intervening periods to promote adherence and modify/update exercise prescription where required. Throughout the intervention phase, all home-based aerobic exercise will be recorded using commercially available heart rate monitors and physical activity trackers provided to each patient. Tailored, individualised exercise plans will be provided to each patient after completion of each supervised visit. Adherence to the intervention will be assessed through documented exercise recorded on heart rate monitors and attendance records for supervised visits maintain by study staff.

Sponsors

University of Adelaide
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

Symptomatic patients with paroxysmal or persistent AF, scheduled for AF ablation, aged between 18 and 80 years (inclusive).

Exclusion criteria

AF ablation within past 12 months. Cardiac surgery or myocardial infarction within the past 12 months. Left ventricular systolic dysfunction (LV Ejection Fraction less than 45%) Significant cardiac valvulopathy (except functional mitral and tricuspid regurgitation). Active malignancy, active autoimmune or systemic inflammatory disease; severe renal or hepatic failure. Unstable ventricular arrhythmias in the preceding 3 months. Inability to participate in an exercise program due to musculoskeletal disease or other active diseases preventing participating in physical exercise. Ongoing participation in exercise program >90 minutes per week. Pregnancy.

Outcome results

None listed

Source: ANZCTR · Data processed: Jul 23, 2026