None listed
Conditions
Brief summary
The purpose of this study is to explore the differences in a type of tumour marker, called a carcinoembryonic antigen, in two different blood sample sites. Who is it for? You may be eligible for this study if you are an adult who has been diagnosed with cancer of either the colon or appendix. Study details All participants in this study will be asked to provide consent for venous blood samples to be taken as part of your peritonectomy surgery. Five ml of blood will be taken from a vein in your arm as well as another 5 ml of blood from the vein near your appendix or right colon that is located in the right lower side of the abdomen during the initial stages of your peritonectomy surgery. All participants will also give access to medical records to collect the relevant study data such as demographic details, diagnosis, treatment, blood and histopathological results. It is hoped that this research will form part of the eventual outcome where we hope to identify patients at risk of developing liver metastases from their colorectal cancer and develop a suitable drug to prevent these patients from developing liver metastases - Improving their prognosis and disease free survival.
Interventions
The only intervention will be to take five ml of blood will be taken from a vein in the patient's arm (this will be from a intravenous cannula as part of the patient's general anaesthetic such that there will be no additional venepuncture burden) as well as another 5 ml of blood from the ileocolic / appendicular vein (a blood vessel that drains blood from the appendix or right colon that is located in the right lower side of the abdomen) during the initial stages of your peritonectomy surgery (t
The only intervention will be to take five ml of blood will be taken from a vein in the patient's arm (this will be from a intravenous cannula as part of the patient's general anaesthetic such that there will be no additional venepuncture burden) as well as another 5 ml of blood from the ileocolic / appendicular vein (a blood vessel that drains blood from the appendix or right colon that is located in the right lower side of the abdomen) during the initial stages of your peritonectomy surgery (total number of blood tests: 2; total volume: 10ml; NB: 5-10mL is equivalent to 1-2 teaspoons). The blood sampling would take less than one minute during surgery by the anaesthetist (peripheral sample) and the surgeon (portal vein sample). Assessment of the fidelity of this intervention will be in part by testing for albumin of these specimens for comparison.
Sponsors
Professor David Morris
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Sex: All * Age range: 18 years and above * Disease status: Appendiceal or right sided colon cancer (suspected or confirmed) * Willingness to give written informed consent and willingness to participate to and comply with the study. * Pre-operative carcino-embryonic antigen (CEA) level > 5 microg/L
Exclusion criteria
* Participants who cannot provide informed consent. * Patients who have had a previous peritonectomy (including those who have previously undergone a right hemicolectomy).
Outcome results
None listed