None listed
Conditions
Brief summary
Contemporary treatment of early oesophageal (food pipe) cancer, involves minimally invasive endoscopic procedures; while surgery is reserved only for cases with the highest-risk of the cancer spreading into the surrounding tissues. The risk of cancer spread is determined by samples removed at endoscopy, in which a pathologist is looking to see the depth of cancer spread into the wall of the oesophagus or for abnormal characteristics of the cancer. The purpose of this study is to try and identify patients who are considered higher risk by conventional practice, who are actually at low risk for cancer spread; and, thus can forgo the need for a major operation with poor post-operative outcomes with respect to quality of life, morbidity and mortality. Who is it for? You may be eligible for this study if you are aged 18 years or older and you have been diagnosed with a high risk oesophageal cancer removed at endoscopy. Study details This observational study will be reviewing the medical records of patients who meet the inclusion criteria only. Participants who meet the inclusion criteria will not be required to attend any additional clinic visits or complete assessments; all relevant information will be extracted from medical records directly. It is hoped this research will determine which patients, with lower risk of cancer spread would be considered candidates for non-surgical management, to avoid an unnecessary (major) oesophageal operation.
Interventions
Observational study in patients who have undergo endoscopic removal of early oesophageal cancers classified as high risk after removal.
As this is a retrospective review, there is no active participation and all data will be from medical records collected as part of routine clinical practice.
After endoscopic removal of a high risk early cancer, patients will be observed for any clinical, radiological or surgical evidence of recurrent/residual cancer. This information is routinely collected a
Observational study in patients who have undergo endoscopic removal of early oesophageal cancers classified as high risk after removal. As this is a retrospective review, there is no active participation and all data will be from medical records collected as part of routine clinical practice. After endoscopic removal of a high risk early cancer, patients will be observed for any clinical, radiological or surgical evidence of recurrent/residual cancer. This information is routinely collected as part of routine clinical care and will simply be collated for analysis at the end of the study period. This is a retrospective study and therefore participants will not be required to complete any questionnaires. The intention is to observe outcomes more than 5 years after initial removal of the high risk cancer however all data will be collect regardless of follow-up interval. All data will be retrospectively collected, however all centers have prospectively collected this data as part of routine clinical care in treatment databases.
Sponsors
WA Cancer Network
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All patients greater than or equal to 18 years-old, with a diagnosis of high risk T1a (HR-IMC) and T1b Oesophageal Adenocarcinoma (OAC) on ELR specimens. (T1a and T1b is not an acronym but rather a T stage so this can't be written out)
Exclusion criteria
• Age < 18 years; • Prior surgery for oesophageal cancer • Known Lymph node or distant metastasis seen on baseline staging EUS, CT or PET
Outcome results
None listed