Assessing diet, exercise, sleep and other lifestyle habits in people with a known increased risk for bowel cancer and who have regular colonoscopies

Dietary and lifestyle behaviour and their association with risk for bowel cancer and pre-Cancerous lesions in individuals undergoing regular colonoscopies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12623000293662

Acronym

RISC

Enrollment

2896

Registered

2023-03-17

Start date

2023-10-02

Completion date

2025-12-29

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will explore how diet and lifestyle, as well as age and gender (and other non-modifiable risk factors), are involved in the development of bowel cancer and pre-cancerous lesions (adenomas) in people considered at above average risk for bowel cancer due to either family history of bowel cancer or prior history of colorectal adenoma. Who is it for? Individuals are eligible to join this study if they are aged 18 years or older, and are currently enrolled in the Southern Cooperative Program for the prevention of colorectal cancer (SCOOP) Program for a surveillance colonoscopy. Study details: All individuals enrolled in the SCOOP program will be invited to complete and return an online or paper survey at years 1, 2 and 3, which will ask questions on diet, exercise, sleep and other lifestyle factors. The results from each survey and the changes in lifestyle over the 3 years will be compared to the findings at the regular surveillance colonoscopies, in particular the presence of advanced colorectal neoplasia (adenoma or cancer). It is hoped that the results of the study will improve the understanding of the interactions between diet and lifestyle behaviour, with the non-modifiable risk factors on the development of advanced neoplasia. It is hoped that this will be useful for identifying high-risk individuals who may benefit from targeted interventions to reduce their risk of developing bowel cancer and reducing the need for unnecessary colonoscopies for lower risk patients.

Interventions

We propose to conduct a prospective observational study to investigate how change in diet and lifestyle patterns over time impacts the development of precancerous colorectal lesions or colorectal cancer in individuals at above average risk of colorectal cancer and undergoing a colonoscopy surveillance - the 'Southern Cooperative Program for the prevention of colorectal cancer' (SCOOP). Data regarding patients' colonoscopies will be extracted from the SCOOP database. Participants enrolled in the SCOOP program will be invited to complete the diet and lifestyle survey over the period of three years (in years 1 (baseline survey), 2 and 3 (follow-up surveys)). The survey can be completed by the participants either online, by clicking on a provided link or scanning a QR code. It is expected that each survey will require around 40-50 minutes to be filled out. The exposure variables include: - Dietary intake (using a validated food frequency questionnaire from the Australian Eating Survey), - Physical activity (using the International Physical Activity Questionnaire (IPAQ-L)), - Sleep patterns (Pittsburgh Sleep Quality Index (PSQI), Obstructive sleep apnoea screening questionnaire (OSAS), and Insomnia Severity Index questionnaire, - Smoking status, - Body mass index (BMI), - Aspirin intake, and - Comorbidities including diabetes.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Individuals enrolled to the SCOOP program (either private and public) due to having either a family history of colorectal cancer, or a personal history of adenoma or colorectal cancer, and who undergo regular surveillance colonoscopy.

Exclusion criteria

Unable to complete the survey (due to language or cognitive issues).

Outcome results