None listed
Conditions
Brief summary
More than 90% of people living with parkinsonism experience non-motor symptoms more frequently and severely than unimpaired people of the same age and gender. Cognitive problems, mood disorders (depression, anxiety, apathy), pain, sleep and wakefulness problems, and fatigue are among the most frequent of these symptoms. Furthermore, these symptoms are reported to contribute to poor health-related quality of life, and some studies suggest this may be more so than that for parkinsonism motor symptoms. The presence of a close symptom-to-symptom interaction between the five non-motor symptoms of interest has been observed in a recent study. Though this finding warrants further exploration, it may provide meaningful insight into how to best manage the collective burden of these symptoms. Emerging evidence from intervention studies suggests that participation in physical exercise may offer potential benefits for managing these non-motor symptoms when usual pharmaceutical care offers limited effectiveness and unwanted side effects. Despite the potential benefits of exercise, physical activity levels among people with parkinsonism often decline following diagnosis and are significantly less than for unimpaired people of the same age. Daily fluctuations in the presence and severity of non-motor symptoms arguably influence daily physical activity behaviour. While worse non-motor symptoms may considerably contribute to the physical inactivity observed by people with parkinsonism, no study has specifically focused on this potential association. This study aims to evaluate the feasibility of using a repeated daily questionnaire delivered for seven consecutive days to monitor daily non-motor symptoms and physical activity behaviour in people with parkinsonism from a New Zealand population. If feasibility is shown, more extensive cohort studies may use the questionnaire to explore (1) the interrelationship between the five non-motor symptoms of interest, (2) whether these symptoms are affected by variations in daily and weekly habitual physical activity behaviour, and (3) whether these symptoms influence daily and weekly habitual physical activity participation.
Interventions
Conditions observed:
1) Physical activity behaviour
2) Five non-motor symptoms = affect, pain, sleep, cognition, and fatigue.
Duration of observation: Seven consecutive days
What is involved for Participants:
1) Complete three short daily questionnaires for seven days (estimated five minutes each).
These will be completed via the m-path app which is a free-to-download smartphone application. For participants who are not able to use a smartphone, paper-based copies of the questionnaires
Conditions observed: 1) Physical activity behaviour 2) Five non-motor symptoms = affect, pain, sleep, cognition, and fatigue. Duration of observation: Seven consecutive days What is involved for Participants: 1) Complete three short daily questionnaires for seven days (estimated five minutes each). These will be completed via the m-path app which is a free-to-download smartphone application. For participants who are not able to use a smartphone, paper-based copies of the questionnaires will be provided. 2) Complete one longer set of questions (estimated time 60 minutes). These questionnaires will require participants to recall their physical activity behaviours and non-motor symptom experiences over the past seven days post-completion of the seven-day EMA-based questions. 3) Complete one motor symptom assessment via video call if possible (estimated time 20 minutes). We will require a total of two to three hours of each participant's time across eight days.
Sponsors
University of Otago
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
- Self-declared diagnosis of idiopathic Parkinsons disease or atypical parkinsonism disorders (Multiple System Atrophy, Progressive Supranuclear Palsy, Corticobasal Degeneration and Dementia with Lewy Bodies) - Adults over 18 years of age - Able to read, understand and respond in English
Exclusion criteria
Nil. For participants who are unable to provide informed consent due to cognitive impairment a supported decision-making process will be used with the help of their chosen caregivers and support persons.
Outcome results
None listed