None listed
Conditions
Brief summary
This observational study will investigate injury characteristics and clinical assessments to measure post-concussion symptoms at different time points in the first year post injury and use this information to predict people who are more likely to have a poor outcome after concussion. Participants will be recruited via hospital emergency departments following initial medical practitioner assessment and concussion diagnosis. Once consented into the study, participants will complete a questionnaire about their concussion injury and medical history, in addition to having a blood and saliva sample taken. Other clinical assessments and an MRI scan will also be completed within 4 days of their injury. At 2 weeks, 1-, 3-, 6- and 12- months following injury, participants will be contacted via telephone to complete a follow up questionnaire about their concussion symptoms and quality of life post injury. Having a better understanding of people who are at risk of developing persistent symptoms following a concussion will enable more targeted and timely clinical care to minimise distress and disability that may be experienced as a result of injury.
Interventions
People who have experienced a mild traumatic brain injury (mTBI) are recruited within 12 hours of their injury. At the time of recruitment, participants will complete a questionnaire about their mTBI in-person with an experienced researcher. Questions will cover the nature of the injury, as well as the person's symptoms, relevant comorbidities, medical history, and general health and lifestyle factors. A blood and saliva sample will also be taken at the time of recruitment, less than 12 hours fo
People who have experienced a mild traumatic brain injury (mTBI) are recruited within 12 hours of their injury. At the time of recruitment, participants will complete a questionnaire about their mTBI in-person with an experienced researcher. Questions will cover the nature of the injury, as well as the person's symptoms, relevant comorbidities, medical history, and general health and lifestyle factors. A blood and saliva sample will also be taken at the time of recruitment, less than 12 hours following injury. Within 4 days of their injury, participants will attend further in-person testing that will include vestibular and balance assessments, further symptomology assessment, computer-based cognitive testing and undergo an MRI scan. The in-person testing will take approximately 3 hours. All participants are followed up by phone at 2 weeks, 1-, 3-, 6- and 12-months following their injury. The follow-up questionnaire is based around self-assessment of symptoms and takes around 10 minutes. The total duration of participation is 1 year post-injury.
Sponsors
Curtin University
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
i) Clinical diagnosis of concussion made by a medical practitioner ii) Aged 14 – 65 years iii) Able to be enrolled within 12 hours of head injury with symptoms attributable to that injury iv) Post-Traumatic Amnesia of less than 24 hours v) No significant findings on acute brain CT scan, or CT scan not required vi) Willing and able to attend additional in-person assessment within 4 days of injury
Exclusion criteria
i) Glasgow Coma Scale <14 at the time of initial assessment ii) Significant history of pre-existing conditions that would interfere with outcome assessment and follow-up (eg. Substance abuse/alcohol abuse, homelessness, terminal illness) iii) Significant debilitating pre-existing diagnosed mental health disorder that would interfere with neuropsychological and possibly blood or saliva biomarker outcome measures or follow up (eg schizophrenia, bipolar disorder) iv) Significant pre-existing neurological condition which may interfere with ability to complete outcome measures or follow up (eg. Stroke, dementia) v) Pre-existing cognitive impairment such as intellectual disability which may interfere with ability to undertake neuropsychological examination vi) Non-English speakers or poor English language skills which may interfere with ability to undertake neuropsychological examination vii) Pregnant women viii) Prisoners in custody or people known to be involved in illegal activity ix) Deemed unlikely to comply with scheduled follow ups (e.g. homeless, alcohol dependence). x) Head injury deemed to be entirely due to primary seizure. xi) Significant other physical trauma that would interfere with physical and/or biochemical outcome assessments and follow up (eg lower limb injuries that would impede balance assessment, neck injuries that would restrict head movements, or cause changes in blood or saliva biomarkers) xii) Epilepsy or history of seizures xiii) Meets exclusion criteria to undertake MRI, which can be any of the following: • Has cardiac pacemaker or pacing wire in situ • Has metal surgical clips or staples of any kind (particularly aneurysm clips) in situ • Has had lap band surgery • Has electronic inner ear implants (bionic ears) • Has metal fragments in your eyes (past or present) • Has electronic stimulators • Has implanted pumps • Has metal pins or rods in bones • Has an IUCD (intrauterine contraceptive device) fitted • Has shrapnel, bullets or foreign bodies
Outcome results
None listed