Evaluation of the performance (accuracy, precision) of a new non-contact and non-invasive hyperparallel optical coherence tomography device in imaging and measuring normal eyes and eyes with diseases.

In this study, subjects (eyes) will be recruited and divided into 6 groups, i.e. cataract, pseudophakic (monofocal or toric IOL), post-refractive surgery (phakic or pseudophakic with monofocal or toric IOL), phakic <30 years with no history of refractive surgery or ocular disease including cataract, corneal cylinder <2 D, phakic <30 years with no history of refractive surgery or ocular disease, corneal cylinder >2 D, and dry eye. After informed consent process and screening examination, for each eligible subject, • 3 acceptable scans/measurements/tests for each modality of biometry, wavefront, topography and tear film assessment will be obtained on HP-OCT+; • 3 acceptable biometry scan/measurements will be obtained from HP-OCT and IOLMaster 700; • 3 acceptable retinal images will be also obtained from HP-OCT+ and HP-OCT; • 3 acceptable scans/measurements for each scan type of wavefront, axial length and topography will be obtained on Innoveyes Sightmap, • 3 acceptable tear film tests will be performed on Keratograph 5M All scans are non-contact and non-invasive. All eligible subjects will receive the same required scans on all the devices as described above. The order of the instrument testing and the eye to be tested first (right versus left) will be randomised for each individual participant using a Latin Square design. The scans will be performed and assessed for acceptability by qualified ophthalmologists, optometrists and/or orthoptists at the study site following the respective device user manual. All scans on a subject will take place in one visit. Each scan attempt is not expected to take more than 1 minute. The total scan time on a subject is expected to be less than 1.5 hour. The repeatability of HP-OCT+ measurements will be characterised. The scan/measurement data of the first acceptable scan will be also compared between HP-OCT+ and the other four comparative instruments. • The biometric data will be compared with HP-OCT, IOLMaster 700 and Innoveyes Sightmap; • The wavefront and topography data will be compared with Innoveyes Sightmap; • The tear film tests data will be compared with Keratograph 5M; and • The retinal images will be compared with HP-OCT.