None listed
Conditions
Brief summary
An unintended but common outcome of bariatric surgeries is reduced preference for sweet and fatty foods. It is not known why this occurs. This study will examine whether changes in food preferences after bariatric surgery are related to changes in taste receptors in the gut. In volunteers undergoing sleeve gastrectomy or gastric bypass, food preferences and gut taste receptors will be examined and compared before and 12 months after surgery. Relationships between food preferences, gut taste receptors, weight loss, blood glucose and lipid profile will be examined. This will indicate whether changes in gut taste receptors are related to the effects of bariatric surgery.
Interventions
Exposure is bariatric surgery (sleeve gastrectomy or Roux-en-Y gastric bypass). Observation period is during the pre-operative work-up period until 12-months post surgery.
Observation involves food and alcohol preference questionnaires, blood tests, weight record, and gastrointestinal biopsies at 3 timepoints: pre-operative work-up, bariatric surgery, and approximately 12 months (range 6-18 months) post-surgical follow-up.
Sponsors
St Vincent's Hospital Melbourne
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adults (age 18 years or over) 2. Waiting to undergo sleeve gastrectomy or Roux-en-Y gastric bypass
Exclusion criteria
1. Using medication for the treatment of diabetes and/or obesity 2. Waiting to undergo revisional surgery 3. Previous intestinal surgery that has resulted in alteration to stomach or small bowel anatomy 4. Unable to provide informed consent
Outcome results
None listed