Systemic inflammation in bariatric surgery

Investigation of the Effect of Obesity Surgery on Inflammatory Markers and Its Relationship with Smoking.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12623000162617

Enrollment

Registered

2023-02-17

Start date

2022-12-15

Completion date

2023-02-01

Last updated

2023-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Obesity can be considered as a widespread pandemic of today. Bariatric surgery is the treatment method for the surgical treatment of morbid obesity. Neutrophil/Lymphocyte ratio (N/L), Platelet/Lymphocyte ratio (T/L) and Systemic Immune Inflammatory Index (Siii) are important inflammatory markers. There are many studies in the literature with the contribution of obesity on inflammatory markers. It was planned to be used as an SII (NeutrophilxPlatenet/Lymphocyte) biomarker based on neutrophil (N), lymphocyte (L) and platelet (P) counts. In the hypothesis that we established in our study, it was accepted that inflammation decreased in the post-bariatric surgery period. . Potential confounders such as smoking, obstructive sleep apnea, and gender may affect the interaction between different inflammatory markers. For this reason, we are planning to test with a control group that does not smoke and does not have any comorbidities, who were operated and followed up.

Interventions

The study was planned as a single-center, controlled and retrospective study. Data obtained from preoperative and postoperative laboratory records of patients who underwent bariatric surgery in Karaman Training and Research Hospital between May 2021 and November 2022 will be evaluated. The parameters planned to be evaluated are SII (NeutrophilxPlatenet/Lymphocyte), Neutrophil/Lymphocyte ratio (N/L), Platelet/Lymphocyte ratio (T/L) based on Neutrophil (N), lymphocyte (L) and platelet (P) counts. The data will be accessed from the electronic database of our hospital. The record to be examined before the operation; the 1-week period before the operation, the record to be examined after the operation; The patient will have hemogram parameters evaluated at the first month and after the operation to the surgical outpatient clinic for control purposes.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Patients over 18 years of age with a diagnosis of morbid obesity who underwent bariatric surgery will be included in the study.

Exclusion criteria

Those who are illiterate in Turkish, those with active psychiatric disorders and those who do not give consent will be excluded from the study.

Outcome results