The effect of preoperative polyunsaturated fatty acid use on perioperative inflammatory response

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Inflammatory process; Secretion of anti-inflammatory cytokines can be regulated by negative feedback mechanisms, including inhibition of proinflammatory signals and loss of receptors to which inflammatory mediators will bind. The association of polyunsaturated fatty acids with inflammation is mediated by the production of eicosanoids. Eicosanoid synthesis occurs through polyunsaturated fatty acids obtained from phospholipids in the cell membrane by the phospholipase A2 enzyme. While there are studies on the use of polyunsaturated fatty acids in different patient groups in the literature, studies on the perioperative period are limited. With this study, it is aimed to show the effects of perioperative omega3-6 fatty acid use. In this study, pregnant women who were planned to deliver by cesarean section under elective conditions, between 1 April 2022 and 31 December 2022, whose physical status is ASA II according to the American Society of Anesthesiology (ASA) classification, over 18 years of age, omega3 and omega6 content of at least 500 mg in total will be included. 30 patients using fish oil supplements will be included. Demographic information of the patients (age, gender, weight, BMI, gestational age, known diseases and medications used during pregnancy) will be recorded. Interleukin-6 and Interleukin-10 serum levels will be studied in the laboratory environment in 3 different time periods, preoperative, postoperative 6th hour and postoperative 24th hour. group omega; Patients who use nutritional supplements containing omega-3 and omega-6 and continue to use them for at least 8 weeks before the operation, group control; It consists of patients who have not used any omega3 and omega6 nutritional supplements for at least 8 weeks. The patients in both groups will undergo the normal surgical procedure. SPSS program will be used for statistical analysis. Descriptive values will be expressed as mean±standard deviation. Chi-Square Test will be used for ASA score and gender assessments. The Kolmogorov-Smirnov Test will be used for the evaluation of all data about the groups. It was planned to evaluate the compatible data with the Student T Test and the inconsistent data with the Mann Witney U Test

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