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Acute Effects of Resistance Exercise with Intra-Set Rest in Older Adults

Acute Effects of Resistance Exercise with Intra-Set Rest on Physiological and Psychological Responses in Healthy Older Adults

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622001573741
Enrollment
30
Registered
2022-12-20
Start date
2023-10-24
Completion date
2024-12-15
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aim of this acute study is to examine the acute effects of resistance exercise performed with ISR compared to TRAD on the maintenance of force, power output, and work, as well as differences between exercises targeting the upper and lower limbs. Secondary aims include whether better affective responses and less physiological and psychological fatigue can be achieved following resistance exercise using ISR compared to TRAD sets. Hypotheses: 1. Resistance exercise performed with ISR will lead to higher mean force, power output, and work across the sets compared to resistance exercise performed with TRAD. 2. Resistance exercise performed with ISR will lead to lower perceived effort and more positive and less negative affective responses compared to resistance exercise performed with TRAD. 3. Resistance exercise performed with ISR will lead to greater muscle oxygenation and blood flow compared to resistance exercise performed with TRAD. 4. Muscle oxygenation and blood flow will explain a significant portion of the variance in power output, velocity, perceived effort, and affective responses between groups. 5. Similar responses for upper versus lower limb resistance exercises will be observed following the ISR and TRAD conditions.

Interventions

The experimental session will be conducted in an exercise clinic at the University of Sydney Camperdown campus (Susan Wakil Health Building). Specifically, the experimental sessions will involve a 5-minute warm-up followed by 30 minutes spent performing the exercises (inclusive of resistance exercise and recovery times). All sessions will be supervised by an exercise physiologist or exercise scientist with one-on-one supervision provided to participants. There will be 7 days between the two experimental sessions (i.e., wash-out). Familiarisation will be conducted at end of an initial testing visit and will involve performing 2 sets of the chest press and the leg press following the exercise prescription used for the intra-set recovery (ISR) condition (details described below). The ISR condition will involve 4 sets of 2 clusters of 5 repetitions at 70% one-repetition maximum (1RM) with 30 seconds of rest between clusters and 90 seconds of rest between sets. Participants will perform the chest press prior to the leg press (in this order). The warm-up during experimental sessions will involve completing 1 set of 8 repetitions for the exercises performed in the session (i.e., chest press or leg press) with a load equivalent to 40% of 1RM. After 2 minutes of rest following the warm-up, participants will commence the first set of the experimental condition. The Keiser A420 pneumatic (air resistance) equipment (Fresno, CA, USA) will be used for the chest press and leg press. Participants will be instructed to refrain from moderate-vigorous exercise and any activities outside of daily living for the previous 72 hours prior to each session. Participants will also be asked not to start any other new exercise regimen or intentionally change their habitual diet throughout the entire study and assessment.

Sponsors

The University of Sydney
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Participants should be able to speak English. Individuals with > 1 year experience in resistance training and have averaged at least 2 sessions of resistance training per week during the previous 6 weeks. Participants need to be free of rotator cuff tear or history of any shoulder or back or lower extremity condition, injuries, surgeries, congenital malformations, back, knee, or hip osteoarthritis, recent fracture (12 months), cognitive impairment as defined by Montreal Cognitive Assessment score of 27-30.

Exclusion criteria

Acute or terminal illness, neuromuscular diseases or disorders, and any unstable or ongoing cardiovascular/respiratory disorders. Individuals taking medications considered to affect muscle performance (e.g., statin, diuretics) will be excluded from the study. Individuals with morbid obesity (BMI > 40).

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026