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Investigating Imagery Rescripting as a Treatment for Unipolar Depression

A randomized controlled trial of Imagery Rescripting for Unipolar Depression in Adults

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622001559707
Enrollment
40
Registered
2022-12-19
Start date
2024-01-15
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aim of this study is to investigate the benefits of three sessions of imagery rescripting (ImR) compared to a waitlist control for depression. The secondary aim is to investigate the proposed mechanisms of action (i.e., negative interpretations of intrusive memories, depressive rumination, early maladaptive schemas and schema modes) that underpin ImR for depression. Participants in the treatment group will begin the intervention immediately, and their results will be compared with a waitlist control condition who will receive the same intervention after a three-week wait period.. Outcome measures will be administered at baseline, post treatment and 1-month follow-up. Based on existing studies of ImR for depression, and ImR for other disorders, it is hypothesised that: 1) ImR will be more effective in reducing symptoms of depression than waitlist control at post-treatment and follow up; and 2) ImR will yield greater improvements in negative interpretations of intrusive memories, depressive rumination, early maladaptive schemas and schema modes, compared to waitlist control.

Interventions

Treatment will be an imagery rescripting (ImR) intervention following the protocol established by Wheatley and colleagues (Brewin et al., 2009; Wheatley et al., 2009; Wheatley & Hackmann, 2011). ImR is a collection of imagery techniques that alter negative meanings associated with autobiographical memories of distressing experiences. Those in the immediate treatment condition will receive three individual weekly (60-90 minute) sessions delivered via an internet videoconferencing platform (Zoom)

Treatment will be an imagery rescripting (ImR) intervention following the protocol established by Wheatley and colleagues (Brewin et al., 2009; Wheatley et al., 2009; Wheatley & Hackmann, 2011). ImR is a collection of imagery techniques that alter negative meanings associated with autobiographical memories of distressing experiences. Those in the immediate treatment condition will receive three individual weekly (60-90 minute) sessions delivered via an internet videoconferencing platform (Zoom). The first treatment session involves participants providing a detailed account of the chosen memory or image, including sensory experience, emotions, cognitions and meanings associated with events. Participants will be asked what they need to happen in the imagery to reduce the distress associated with events, then guided to visualise this modification or alternative outcome (e.g., introducing safety, control, compassion, nurturance). Subsequent sessions will involve replication of the rescript with modifications as necessary, and rescripting of additional intrusive memories/images that are identified. Following the three-week waitlist period, participants in the waitlist control condition will be offered the same three-session ImR intervention. Treatment will be delivered by fully registered psychologists and clinical psychologists under the supervision of an experienced clinical psychologist. All treating psychologists will be thoroughly trained in the administration of the treatment protocol by the project investigators. All sessions will be recorded and at least 10% of sessions will be randomly selected for treatment fidelity.

Sponsors

University of Technology Sydney
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Adult (minimum 18 years old) 2. English speaking 3. Able and willing to provide written informed consent 4. Meets Diagnostic and Statistical Manual (DSM-5-TR, 2022) criteria for a current principal diagnosis of Major Depressive Disorder and/or Persistent Depressive Disorder (as assessed via the Diagnostic Interview for Anxiety Mood, OCD, and Related Neuropsychiatric Disorders [DIAMOND]; Tolin et al., 2018).

Exclusion criteria

1. Principal mental health diagnosis other than Major Depressive Disorder or Persistent Depressive Disorder (as assessed via the DIAMOND; Tolin et al., 2018). 2. Current engagement in other psychological treatment 3. Current active psychotic symptoms 4. Current active suicidal or homicidal ideation, or significant risk of harm to self or others. 5. Significant cognitive/intellectual impairment as assessed during diagnostic interview 6. Do not have access to a computer with a camera and stable internet on a regular basis

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026