None listed
Conditions
Brief summary
Cancer patients often experience inflammation, which is thought to be associated with cancer development and progression, as well as being linked to side effects experienced during and after treatment. As exercise is known to have an effect on systemic inflammation, the aim of this project is to investigate the effect of exercise intensity on markers of inflammation in patients with cancer. Who is it for? You may be eligible for this study if you are aged 18 years or older, have been diagnosed with any cancer type, and are 3-12 months post-completion of primary cancer treatment with curative intent. Study details Participants who enrol in this study will be randomly allocated by chance (similar to flipping a coin) to begin with 2 weeks of either low- or high-intensity exercise involving stationary cycling. Participants will complete 3, 25 minute (total time required per visit: 1 hour) exercise sessions per week (i.e. 6 sessions in total) supervised by an accredited exercise physiologist. After completing the 2-week program, participants will take a 6-week break before switching over to the other intensity for a further two weeks. Blood samples and tests of muscle pain will be performed before each 2-week exercise period, after the first session of each exercise period, and at the end of each 2-week exercise period. It is hoped this research will help us to determine the intensity of exercise that best reduces markers of inflammation in cancer patients, with improvements in cancer pain.
Interventions
A randomised crossover design where participants are randomised to either high intensity (60-70% Heart rate reserve) or low intensity (30-40% heart rate reserve) aerobic exercise (stationary cycling) for 2-weeks (6 exercise sessions; 3 per week for 2 weeks, 30 mins total duration per session; 5 min warmup, 20 mins at prescribed intensity, 5 mins cooldown). After the completion of the two-week intervention, the participants undergo a 6-week washout period followed by the opposite exercise intensi
A randomised crossover design where participants are randomised to either high intensity (60-70% Heart rate reserve) or low intensity (30-40% heart rate reserve) aerobic exercise (stationary cycling) for 2-weeks (6 exercise sessions; 3 per week for 2 weeks, 30 mins total duration per session; 5 min warmup, 20 mins at prescribed intensity, 5 mins cooldown). After the completion of the two-week intervention, the participants undergo a 6-week washout period followed by the opposite exercise intensity intervention. The exercise sessions delivered one-on-one and are supervised by an accredited exercise physiologist who is a member of the research team. The exercise sessions take place in a specialized exercise laboratory in the Wallace Wurth Building, Department of Exercise Physiology at UNSW. HR monitors are used to monitor continuous heart rate to determine compliance with the exercise prescription. Attendance at exercise sessions is recorded to measure adherence to the intervention.
Sponsors
University of New South Wales
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
People 3-12 months post completion of primary cancer treatment with curative intent. Any cancer type.
Exclusion criteria
- Currently undergoing active cancer treatment. - Currently taking any regular anti-inflammatory medication. - Currently taking any regular analgesic medication. - Pregnant or breastfeeding women. - Anyone on an experimental drug trial. - Anyone who could not freely give informed consent.
Outcome results
None listed