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The incidence and significance of post-operative respiratory depression amongst surgical patients receiving intrathecal morphine

The incidence and significance of post-operative respiratory depression amongst surgical patients receiving intrathecal morphine

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12622001481763
Enrollment
698
Registered
2022-11-25
Start date
2020-07-01
Completion date
2022-10-03
Last updated
2022-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to determine the incidence of respiratory depression in post-surgical patients who received intrathecal morphine, and whether those patients that develop respiratory depression have an increased risk of post-operative complications.

Interventions

This study will describe the incidence and clinical significance of respiratory depression after the administration of intrathecal morphine amongst adult surgical patients at Austin Health between 2017 and 2022 who were extubated and were admitted to the intensive care or high dependency unit post-operatively. Data collected will include: patient demographics, comorbidities, surgical details, anaesthetic details, clinical observations, blood gases, laboratory investigations, radiology reports,

This study will describe the incidence and clinical significance of respiratory depression after the administration of intrathecal morphine amongst adult surgical patients at Austin Health between 2017 and 2022 who were extubated and were admitted to the intensive care or high dependency unit post-operatively. Data collected will include: patient demographics, comorbidities, surgical details, anaesthetic details, clinical observations, blood gases, laboratory investigations, radiology reports, complications, discharge details and mortality data. As this is a retrospective study, there is no participant involvement. Data will be collected from the electronic medical records. Participants will be followed up until 90 days post-operatively.

Sponsors

Dr Luke Fletcher
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Adult patient, greater than or equal to 18 years Underwent surgery at Austin Health Received intrathecal morphine Admitted to the intensive care / high dependency unit post-operatively Not intubated post-operatively

Exclusion criteria

Intrathecal catheter placement with ongoing infusion of intrathecal opioid

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026